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產(chǎn)品名稱(chēng)

ML 252

產(chǎn)品貨號(hào)

Axon 2615 CAS [N.A.] MF C20H24N2O.HClMW 344.88 Purity: 99% Soluble in DMSO Description Potent, selective and brain penetrant KCNQ2 inhibitor (Kv7.2; IC50 value 69 nM, and >40-fold selective over KCNQ1). A useful in vivo tool molecule to study KCNQ2 pharmocology. KEYWORDS:?ML 252 | supplier | KCNQ2 inhibitor | ML-252 | CAS [1392494-64-2] - [1392494-65-3] | Potassium | voltage-gated | Kv7.2 | Alzheimer’s | brain penetrant | selective | KCNQ1 | CNS

產(chǎn)品價(jià)格

現(xiàn)貨詢(xún)價(jià)，電話(huà)：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

ML 252

Based on 116 reference(s) in Google Scholar 8 10 116

Axon 2615

CAS [N.A.]

MF C20H24N2O.HCl
MW 344.88

Purity: 99%
Soluble in DMSO

ML 252

Description

Potent, selective and brain penetrant KCNQ2 inhibitor (Kv7.2; IC50 value 69 nM, and >40-fold selective over KCNQ1). A useful in vivo tool molecule to study KCNQ2 pharmocology.

KEYWORDS:?ML 252 | supplier | KCNQ2 inhibitor | ML-252 | CAS [1392494-64-2] - [1392494-65-3] | Potassium | voltage-gated | Kv7.2 | Alzheimer’s | brain penetrant | selective | KCNQ1 | CNS

YY Cheung et al. Discovery of a series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as novel molecular switches that modulate modes of K(v)7.2 (KCNQ2) channel pharmacology: identification of (ML252)… J Med Chem. 2012 Aug 9;55(15):6975-9.

Certificate of Analysis
Material Safety Data Sheet

Cardiovascular CNS Pain & Inflammation Kv7.2 KCNQ2

Selective and brain penetrant KCNQ2 inhibitor

Chemical name

(S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide hydrochloride

Parent CAS No.

[1392494-64-2]

產(chǎn)品資料

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