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產品名稱

KN 93

產品貨號

產品價格

現(xiàn)貨詢價，電話：010-67529703

產品規(guī)格

產品品牌

axonmedchem

產品概述

產品詳情

KN 93

Based on 514 publications in PubMed 9 10 514

Axon 2566

CAS [1188890-40-5]

MF C26H29ClN2O4S
MW 501.04

Purity: 99%
Soluble in DMSO

KN 93

Description

Inhibitor of multifunctional Ca2+/Calmodulin-dependent protein kinase (CaMKII; Ki value 0.37 μM for inhibition of CaMKII phosphorylating activity). In addition, KN93 also affects CaV1.3 and CaV1.2 calcium channels in a CaMKII-independent manner.

The water soluble phosphate salt of KN 93 (Axon 2555) is available as well.

M Sumi et al. The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells. Biochem Biophys Res Commun. 1991 Dec 31;181(3):968-75.

ME Anderson et al. KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J Pharmacol Exp Ther. 1998 Dec;287(3):996-1006.

L Gao et al. CaMKII-independent effects of KN93 and its inactive analog KN92: reversible inhibition of L-type calcium channels. Biochem Biophys Res Commun. 2006 Jul 14;345(4):1606-10.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cardiovascular Cell Cycle Regulation CNS CaMK EC 2.7.11.17

Inhibitor of multifunctional Ca2+/Calmodulin-dependent protein kinase CaMKII

Chemical name

(E)-N-(2-(((3-(4-chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide

Parent CAS No.

[1188890-40-5]

產品資料

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