| 產(chǎn)品名稱 | LRRK2-IN-1 |
| 產(chǎn)品貨號 | Axon 2493 CAS [1234480-84-2] MF C31H38N8O3MW 570.69 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Potent, ATP-competitive and selective inhibitor of the Parkinson's disease kinase LRRK2 (IC50 value 13 nM and 6 nM for inhibitions of WT and G2019S mutant LRRK2 kinase activity, respectively). LRRK2IN1 is neuroprotective in vitro and inhibits the activity of LRRK2 in kidney and spleen when administered in vivo. However, LRRK 2-IN-1 is not able to cross the BBB. References Certificates Categories Extra info B.K. Gilsbach et al. Structural Characterization of LRRK2 Inhibitors. J Med Chem. 2015 May 14;58(9):3751-6. ? X. Deng et al. Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2. Nat Chem Biol. 2011 Apr;7(4):203-5. ? L. Munoz et al. Optimisation of LRRK2 inhibitors and assessment of functional efficacy in cell-based models of neuroinflammation. Eur J Med Chem. 2015 May 5;95:29-34. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Signaling & Oncology CNS Pain & Inflammation LRRK2 Ubiquitin EC 2.7.11.1 Potent, ATP-competitive and selective inhibitor of LRRK2 Chemical name 2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one Parent CAS No. [1234480-84-2] Order Size Unit Price Stock 5 mg €85.00 In Stock |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
LRRK2-IN-1Axon 2493 CAS [1234480-84-2] MF C31H38N8O3
Description
Potent, ATP-competitive and selective inhibitor of the Parkinson's disease kinase LRRK2 (IC50 value 13 nM and 6 nM for inhibitions of WT and G2019S mutant LRRK2 kinase activity, respectively). LRRK2IN1 is neuroprotective in vitro and inhibits the activity of LRRK2 in kidney and spleen when administered in vivo. However, LRRK 2-IN-1 is not able to cross the BBB.
Potent, ATP-competitive and selective inhibitor of LRRK2
Chemical name2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one Parent CAS No.[1234480-84-2] |
| 產(chǎn)品資料 |
