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產(chǎn)品名稱

PF 04447943 - PF 4447943

產(chǎn)品貨號(hào)

Axon 2148 CAS [1082744-20-4] MF C20H25N7O2MW 395.46 Purity: 99% Optical purity: Optically pure Soluble in 0.1N HCl(aq) and DMSO Description Selective, brain penetrant PDE9A inhibitor for the treatment of cognitive disorders that exhibit a disrupted P50-gating response (IC50 values 8.3 nM and 1394 nM for PDE9A and PDE1C respectively). PF 04447943 elevates cGMP in multiple brain regions and in cerebral spinal fluid (CSF), and shows an impact on hippocampal synaptic plasticity. References Certificates Categories Extra info P.R. Verhoest et al. Design and discovery of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943),..... J. Med. Chem. 2012, 55, 9045-9054. ? M.M. Claffey et al. Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors. J. Med. Chem. 2012, 55, 9055-9068. Certificate of Analysis Material Safety Data Sheet Cardiovascular Cell Signaling & Oncology CNS Pain & Inflammation EC 3.1.4.35 PDE Selective, brain penetrant PDE9A inhibitor Chemical name 6-((3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one Parent CAS No. [1082744-20-4] Order Size Unit Price Stock 2 mg €105.00 In Stock

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

PF 04447943 - PF 4447943

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2148

CAS [1082744-20-4]

MF C20H25N7O2
MW 395.46

Purity: 99%
Optical purity: Optically pure
Soluble in 0.1N HCl(aq) and DMSO

PF 04447943

Description

Selective, brain penetrant PDE9A inhibitor for the treatment of cognitive disorders that exhibit a disrupted P50-gating response (IC50 values 8.3 nM and 1394 nM for PDE9A and PDE1C respectively). PF 04447943 elevates cGMP in multiple brain regions and in cerebral spinal fluid (CSF), and shows an impact on hippocampal synaptic plasticity.

P.R. Verhoest et al. Design and discovery of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943),..... J. Med. Chem. 2012, 55, 9045-9054.

M.M. Claffey et al. Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors. J. Med. Chem. 2012, 55, 9055-9068.

Certificate of Analysis
Material Safety Data Sheet

Cardiovascular Cell Signaling & Oncology CNS Pain & Inflammation EC 3.1.4.35 PDE

Selective, brain penetrant PDE9A inhibitor

Chemical name

6-((3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one

Parent CAS No.

[1082744-20-4]

產(chǎn)品資料

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