| 產(chǎn)品名稱 | LY 2811376 |
| 產(chǎn)品貨號(hào) | Axon 2225 CAS [1194044-20-6] MF C15H14F2N4SMW 320.36 Purity: 99% Soluble in 0.1N HCl(aq), DMSO, and Ethanol Description The first orally available non-peptidic BACE 1 inhibitor (IC50 value ranges from 239-249 nM in vitro) that produces profound Aβ-lowering effects in animals. LY2811376 demonstrated ~10-fold selectivity toward BACE 1 over BACE 2, and >50-fold selectivity over cathepsin D, pepsin, or renin. Clinical development of LY 2811376 was terminated as a result of toxicology findings identified in longer-term preclinical studies. References Certificates Categories Extra info P.C. May et al. Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor. J. Neurosci. 2011, 31, 16507-16516.? ? Y. Lu et al. Cerebrospinal fluid amyloid-β (Aβ) as an effect biomarker for brain Aβ lowering verified by quantitative preclinical analyses. J. Pharmacol. Exp. Ther. 2012, 342, 366-375.? Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology CNS BACE-1 EC 3.4.23.46 The first orally available non-peptidic BACE 1 inhibitor Chemical name (S)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine Parent CAS No. [1194044-20-6] Order Size Unit Price Stock 5 mg €125.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
LY 2811376Axon 2225 CAS [1194044-20-6] MF C15H14F2N4S
Description
The first orally available non-peptidic BACE 1 inhibitor (IC50 value ranges from 239-249 nM in vitro) that produces profound Aβ-lowering effects in animals. LY2811376 demonstrated ~10-fold selectivity toward BACE 1 over BACE 2, and >50-fold selectivity over cathepsin D, pepsin, or renin. Clinical development of LY 2811376 was terminated as a result of toxicology findings identified in longer-term preclinical studies.
The first orally available non-peptidic BACE 1 inhibitor
Chemical name(S)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine Parent CAS No.[1194044-20-6] |
| 產(chǎn)品資料 |
