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產(chǎn)品名稱

SB 742457 hydrochloride - GSK 742457 HCl | Intepirdine HCl

產(chǎn)品貨號(hào)

Axon 1382 CAS [607742-55-2] MF C19H19N3O2S.HClMW 389.90 Purity: 99% Soluble in DMSO Description Selective 5-HT6 antagonist; a potential agent added to stabilize donepezil (Axon 1438) treatment in subjects with mild-to-moderate Alzheimer's disease. KEYWORDS:?SB 742457 hydrochloride | supplier | 5-HT6 antagonist | GSK 742457 HCl | Intepirdine HCl | SB-742457 | GSK-742457 | CAS [607742-55-2] | [607742-69-8] | Serotonin | 5-HT6 | CNS | donepezil | Alzheimer's disease | AD | GPCR

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

SB 742457 hydrochloride - GSK 742457 HCl | Intepirdine HCl

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 1382

CAS [607742-55-2]

MF C19H19N3O2S.HCl
MW 389.90

Purity: 99%
Soluble in DMSO

SB 742457 hydrochloride

Description

Selective 5-HT6 antagonist; a potential agent added to stabilize donepezil (Axon 1438) treatment in subjects with mild-to-moderate Alzheimer's disease.

KEYWORDS:?SB 742457 hydrochloride | supplier | 5-HT6 antagonist | GSK 742457 HCl | Intepirdine HCl | SB-742457 | GSK-742457 | CAS [607742-55-2] | [607742-69-8] | Serotonin | 5-HT6 | CNS | donepezil | Alzheimer's disease | AD | GPCR

N Idris et al. Sertindole improves sub-chronic PCP-induced reversal learning and episodic memory deficits in rodents: involvement of 5-HT(6) and 5-HT (2A) receptor mechanisms. Psychopharmacology 2010, 208 (1), 23–36.

G Maher-Edwards et al. Double-Blind, Controlled Phase II Study of a 5-HT6 Receptor Antagonist, SB-742457, in Alzheimer's Disease. Curr. Alzheimer Res. 2009,?7(5), 374-385.

G Rossé G and H Schaffhauser. 5-HT(6) Receptor Antagonists as Potential Therapeutics for Cognitive Impairment. Curr. Top. Med. Chem. 2010, 10(2), 207-221.

N Upton et al. 5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease. Neurotherapeutics 2008, 5(3), 458–469.

Mitchell E.S. et al. 5-HT6 receptors: a novel target for cognitive enhancement. Pharmacol Ther. 2005, 108(3), 320-333.

Certificate of Analysis
Material Safety Data Sheet

CNS 5-HT6 A17

5-HT6 antagonist

Chemical name

3-Benzenesulfonyl-8-piperazin-1-yl-quinoline hydrochloride

Parent CAS No.

[607742-69-8]

產(chǎn)品資料

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