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產(chǎn)品名稱

Rolipram, (R)-(-)-

產(chǎn)品貨號

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

Rolipram, (R)-(-)-

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 1229

CAS [85416-75-7]

MF C16H21NO3
MW 275.34

Purity: 99%
Optical purity: >98% ee
Soluble in DMSO and Ethanol

Rolipram, (R)-(-)-

Description

PDE4 inhibitor, more active R-enantiomer of Rolipram (Axon 1212) in comparison with (S)-(+)-Rolipram (Axon 1432). Rolipram is an anti-inflammatory drug; also with rich CNS profile, such as antidepressive, antipsychotic effects and/or neuroprotection.

HH Schneider et al. Stereospecific binding of the antidepressant rolipram to brain protein structures. Eur J Pharmacol. 1986, 127(1-2), 105-15.?

DE Griswold et al. Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory response. Inflammation. 1993, 17(3), 333–44.

SJ Kanes et al. Rolipram: A specific phosphodiesterase 4 inhibitor with potential antipsychotic activity. Neuroscience. 2006, 144, 239-46.?PMID 17081698

RW Chen et al. Broad spectrum neuroprotection profile of phosphodiesterase inhibitors as related to modulation of cell-cycle elements and caspase-3 activation. Neuroscience Letters. 2007, 418(2). 165–9.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology CNS Pain & Inflammation EC 3.1.4.53 PDE

PDE4 inhibitor

Chemical name

(R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolidin-2-one

Parent CAS No.

[85416-75-7]

產(chǎn)品資料

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