| 產(chǎn)品名稱 | Alofanib - RPT835 | ES000835 |
| 產(chǎn)品貨號 | Axon 2930 CAS [1612888-66-0] MF C19H15N3O6SMW 413.40 Purity: 99% Soluble in 0.1N NaOH(aq) and DMSO Description Alofanib is an allosteric inhibitor of FGFR2 and significantly inhibited bFGF-induced proliferation of HUVEC cells (IC50 value of 11 nM) and suppressed proliferation of SVEC-4-10 cells (IC50 value of 58 nM). Moreover, Alofanib suppressed the migration activity of endothelial cells, and their ability to form vessel-like structures in vitro. Also, Alofanib significantly decreased the number of microvessels in Matrigel implant and in ovarian cancer (SKOV-3) xenograft in vivo. KEYWORDS: Alofanib | supplier | FGFR2 inhibitor | RPT835 | ES000835 | RPT 835 | RPT-835 | ES 000835 | ES-000835 | CAS [1612888-66-0] | FGF | FGFR | Inhibitor | Receptors | Ovarian cancer |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
Alofanib - RPT835 | ES000835Axon 2930 CAS [1612888-66-0] MF C19H15N3O6S
DescriptionAlofanib is an allosteric inhibitor of FGFR2 and significantly inhibited bFGF-induced proliferation of HUVEC cells (IC50 value of 11 nM) and suppressed proliferation of SVEC-4-10 cells (IC50 value of 58 nM). Moreover, Alofanib suppressed the migration activity of endothelial cells, and their ability to form vessel-like structures in vitro. Also, Alofanib significantly decreased the number of microvessels in Matrigel implant and in ovarian cancer (SKOV-3) xenograft in vivo. KEYWORDS: Alofanib | supplier | FGFR2 inhibitor | RPT835 | ES000835 | RPT 835 | RPT-835 | ES 000835 | ES-000835 | CAS [1612888-66-0] | FGF | FGFR | Inhibitor | Receptors | Ovarian cancer
Allosteric inhibitor of FGFR2
Chemical name3-(N-(4-Methyl-2-nitro-5-(pyridin-3-yl)phenyl)sulfamoyl)benzoic acid Parent CAS No.[1612888-66-0] |
| 產(chǎn)品資料 |
