| 產(chǎn)品名稱 | Stem Cell LSC inhibitor Set |
| 產(chǎn)品貨號 | Axon 5005 CAS [N.A.] MF #N/AMW #N/A Purity: 99% Soluble in DMSO Description A convenient set of BMP inhibitor LDN 193189 hydrochloride (Axon 1509), TGF-beta inhibitor SB 431542 (Axon 1661) and GSK-3 inhibitor CHIR 99021 (Axon 1386) (termed as LSC or LSB/CHIR by their name abbreviation), for differentiation of human pluripotent stem cells (hPSCs). Combining two-factor neuronal programming with small molecule–based inhibition of GSK-3β by CHIR 99021 (2 μM) and SMAD signaling by LDN 193189 (0.5 μM) and SB 431542 (10 μM), converted postnatal human fibroblasts into functional neuron-like cells with yields up to >200% and neuronal purities up to >80%. LSC (or LSB/CHIR) inhibitor cocktail protocol can be further extended; with adding SU 5402 (Axon 1667) and DAPT (Axon 1484) to form LSB3i, a 5i inhibitor set (Axon 5007), for rapid differentiating hPSCs into nociceptors. Read more: Additional Product Information Show all Axon Ligand??Sets References Certificates Categories Extra info J. Ladewig et al. Small molecules enable highly efficient neuronal conversion of human fibroblasts. Nat Methods. 2012, 9, 575-578. ? S.M. Chambers et al. Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors. Nature Biotechnol. 2012, 30, 715-720. ? List of publications using LDN 193189 hydrochloride (Axon 1509) purchased from Axon Medchem? List of publications using CHIR 99021 (Axon 1386) purchased from Axon Medchem Certificate of Analysis Material Safety Data Sheet Additional Product Information Apoptosis Cell Signaling & Oncology CNS Diabetes & Metabolism Immunology Pain & Inflammation Stem Cell GSK-3 Wnt-β-Catenin TGF-β PI3K-Akt-mTOR Stem Cells Stem Cell Differentiator BMP-ALK TGF-βR Set of LDN 193189 HCl, SB 431542 and CHIR 99021, inhibitors of BMP, TGF-β, and GSK-3 resp. Chemical name N.A. Parent CAS No. [N.A.] Order Size Unit Price Stock Each 2 mg €145.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
Stem Cell LSC inhibitor SetAxon 5005 CAS [N.A.] MF #N/A
DescriptionA convenient set of BMP inhibitor LDN 193189 hydrochloride (Axon 1509), TGF-beta inhibitor SB 431542 (Axon 1661) and GSK-3 inhibitor CHIR 99021 (Axon 1386) (termed as LSC or LSB/CHIR by their name abbreviation), for differentiation of human pluripotent stem cells (hPSCs). Combining two-factor neuronal programming with small molecule–based inhibition of GSK-3β by CHIR 99021 (2 μM) and SMAD signaling by LDN 193189 (0.5 μM) and SB 431542 (10 μM), converted postnatal human fibroblasts into functional neuron-like cells with yields up to >200% and neuronal purities up to >80%. LSC (or LSB/CHIR) inhibitor cocktail protocol can be further extended; with adding SU 5402 (Axon 1667) and DAPT (Axon 1484) to form LSB3i, a 5i inhibitor set (Axon 5007), for rapid differentiating hPSCs into nociceptors. Read more: Additional Product Information Show all Axon Ligand??Sets ? List of publications using LDN 193189 hydrochloride (Axon 1509) purchased from Axon Medchem? List of publications using CHIR 99021 (Axon 1386) purchased from Axon Medchem
Set of LDN 193189 HCl, SB 431542 and CHIR 99021, inhibitors of BMP, TGF-β, and GSK-3 resp.
Chemical nameN.A. Parent CAS No.[N.A.] |
| 產(chǎn)品資料 |
