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產(chǎn)品名稱

SB 431542

產(chǎn)品貨號

Axon 1661 CAS [301836-41-9] MF C22H16N4O3MW 384.39 Purity: 99% Soluble in DMSO Description Potent and selective inhibitor of TGF-β1 superfamily activin receptor-like kinase (ALK), specifically at ALK5 (IC50: 94 nM) and its relatives ALK4 (IC50: 140 nM) and ALK7; SB431542 inhibits endogenous activin and TGF-β signaling, but has no effect on BMP signaling; a useful tool for studing the role of TGF-β, activin and many cellular processes. *Promotion

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

SB 431542

Based on 413 publications in PubMed 10 10 413

Axon 1661

CAS [301836-41-9]

MF C22H16N4O3
MW 384.39

Purity: 99%
Soluble in DMSO

SB 431542

Description

Potent and selective inhibitor of TGF-β1 superfamily activin receptor-like kinase (ALK), specifically at ALK5 (IC50: 94 nM) and its relatives ALK4 (IC50: 140 nM) and ALK7; SB431542 inhibits endogenous activin and TGF-β signaling, but has no effect on BMP signaling; a useful tool for studing the role of TGF-β, activin and many cellular processes.

*Promotion: SB 431542 is also part of Inhibitor Set(s):

Axon 5004	Axon 5005	Axon 5007
Axon 5009

NJ Laping et al. Inhibition of transforming growth factor (TGF)-b1-induced extracellular matrix with a novel inhibitor of the TGF-b type I receptor kinase activity: SB-431542. Mol. Pharmacol. 2002, 62 58-64.

GJ Inman et al. SB-431542 is a potent and specific inhibitor of transforming growth factor-b superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol. Pharmacol. 2002, 62 65-74.

S Matsuyama et al. SB-431542 and Gleevec inhibit transforming growth factor-b-induced proliferation of human osteosarcoma cells. Cancer Res. 2003, 63 7791-7798.

MD Hjelmeland et al. SB-431542, a small molecule transforming growth factor-β-receptor antagonist, inhibits human glioma cell line proliferation and motility. Mol. Cancer Ther. 2004, 3, 737.

List of publications using SB 431542 (Axon 1661) purchased from Axon Medchem

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Signaling & Oncology Stem Cell TGF-β RSTK class I; EC 2.7.11.30 TGF-βR

TGF-βR1 inhibitor; ALK inhibitor

Chemical name

4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide

Parent CAS No.

[301836-41-9]

產(chǎn)品資料

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