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產(chǎn)品名稱(chēng)

ML352 - VU0476201

產(chǎn)品貨號(hào)

產(chǎn)品價(jià)格

現(xiàn)貨詢(xún)價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

ML352 - VU0476201

Based on 7 reference(s) in Google Scholar 9 10 7

Axon 2587

CAS [1649450-12-3]

MF C21H29N3O4
MW 387.47

Purity: 98%
Soluble in 0.1N HCl (aq) and DMSO

ML352

Description

Potent and selective inhibitor of the presynaptic choline transporter (CHT; Ki value 92 nM). ML352 exhibited no inhibition of acetylcholinesterase (AChE) or cholineacetyltransferase (ChAT) and also lacked activity at dopamine, serotonin, and norepinephrine transporters, as well as many receptors and ion channels.

SR Bollinger et al. Synthesis and structure-activity relationships of a series of 4-methoxy-3-(piperidin-4-yl)oxy benzamides as novel inhibitors of the presynaptic choline transporter. Bioorg Med Chem Lett. 2015 Apr 15;25(8):1757-60.

EA Ennis et al. Identification and characterization of ML352: a novel, noncompetitive inhibitor of the presynaptic choline transporter. ACS Chem Neurosci. 2015 Mar 18;6(3):417-27.

JL Bertron et al. Optimization of the choline transporter (CHT) inhibitor ML352: Development of VU6001221, an improved in vivo tool compound. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4637-40.

Certificate of Analysis
Material Safety Data Sheet

CNS CHT

Potent and selective inhibitor of the presynaptic choline transporter CHT

Chemical name

N-((3-isopropylisoxazol-5-yl)methyl)-4-methoxy-3-(1-methylpiperidin-4-yloxy)benzamide

Parent CAS No.

[1649450-12-3]

產(chǎn)品資料

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