| 產(chǎn)品名稱 | Nintedanib - BIBF-1120 |
| 產(chǎn)品貨號(hào) | Axon 2648 CAS [656247-17-5] MF C31H33N5O4MW 539.62 Purity: 100% Soluble in 0.1N HCl(aq) and DMSO Description Orally bioavailable, indolinone-derived, receptor tyrosine kinase (RTK) inhibitor with potential antiangiogenic and antineoplastic activities that simultaneously targets VEGFR1-3 (IC50 values 34 nM, 21 nM, and 13 nM, resp.), PDGFRα and β (IC50 values 59 and 65 nM), and FGFR1-3 (IC50 values 69 nM, 37 nM, and 108 nM, resp). In addition, BIBF1120 also inhibits members of the Src family of tyrosine kinases, including Src, Lck, Lyn, and FLT-3 (IC50 values 156 nM, 16 nM, 195 nM, and 26 nM, resp.). KEYWORDS:?Nintedanib | supplier | RTK inhibitor | Angiokinase inhibitor | BIBF-1120 | BIBF1120 | Intedanib | CAS [656247-17-5] - [656247-18-6] | PDGF-FGF-VEGF | PDGFR | FGFR | VEGFR | Receptor tyrosine kinase | Src | Lck | Lyn | FLT-3 | antiangiogenic | antineoplastic | antitumor |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
Nintedanib - BIBF-1120Axon 2648 CAS [656247-17-5] MF C31H33N5O4
DescriptionOrally bioavailable, indolinone-derived, receptor tyrosine kinase (RTK) inhibitor with potential antiangiogenic and antineoplastic activities that simultaneously targets VEGFR1-3 (IC50 values 34 nM, 21 nM, and 13 nM, resp.), PDGFRα and β (IC50 values 59 and 65 nM), and FGFR1-3 (IC50 values 69 nM, 37 nM, and 108 nM, resp). In addition, BIBF1120 also inhibits members of the Src family of tyrosine kinases, including Src, Lck, Lyn, and FLT-3 (IC50 values 156 nM, 16 nM, 195 nM, and 26 nM, resp.). KEYWORDS:?Nintedanib | supplier | RTK inhibitor | Angiokinase inhibitor | BIBF-1120 | BIBF1120 | Intedanib | CAS [656247-17-5] - [656247-18-6] | PDGF-FGF-VEGF | PDGFR | FGFR | VEGFR | Receptor tyrosine kinase | Src | Lck | Lyn | FLT-3 | antiangiogenic | antineoplastic | antitumor
RTK inhibitor with antiangiogenic and antineoplastic activities
Chemical name(Z)-methyl 3-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate Parent CAS No.[656247-17-5] |
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