| 產(chǎn)品名稱 | AZD 3759 |
| 產(chǎn)品貨號(hào) | Axon 2563 CAS [1626387-80-1] MF C22H23ClFN5O3MW 459.90 Purity: 98% Optical purity: Optically pure Soluble in 0.1N HCl(aq) and DMSO Description Potent, orally active, brain-penetrant, EGFR tyrosine kinase inhibitor (IC50 value 7.2 nM for inhibition of cellular phosphorylation on L858R cell lines), that shows tumor regression in the mouse model with brain metastasis. At 1 μM, AZD 3759 showed less than 50% inhibition against 115 out of a panel of 124 recombinant protein and lipid kinases, and was neither a direct inhibitor nor a time-dependent inhibitor for a series of Cytochrome isoforms, suggesting a low enzyme induction liability. KEYWORDS: AZD 3759 | supplier | EGFR inhibitor | AZD3759 | CAS [1626387-80-1] | [1626387-81-2] | EGF | EGFR | Inhibitor | orally active | brain-penetrant | RTK | CNS | tumor regression | metastases | clinical trial | central nervous system |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
AZD 3759Axon 2563 CAS [1626387-80-1] MF C22H23ClFN5O3
DescriptionPotent, orally active, brain-penetrant, EGFR tyrosine kinase inhibitor (IC50 value 7.2 nM for inhibition of cellular phosphorylation on L858R cell lines), that shows tumor regression in the mouse model with brain metastasis. At 1 μM, AZD 3759 showed less than 50% inhibition against 115 out of a panel of 124 recombinant protein and lipid kinases, and was neither a direct inhibitor nor a time-dependent inhibitor for a series of Cytochrome isoforms, suggesting a low enzyme induction liability. KEYWORDS: AZD 3759 | supplier | EGFR inhibitor | AZD3759 | CAS [1626387-80-1] | [1626387-81-2] | EGF | EGFR | Inhibitor | orally active | brain-penetrant | RTK | CNS | tumor regression | metastases | clinical trial | central nervous system
Potent, orally active, brain-penetrant, EGFR tyrosine kinase inhibitor
Chemical name(R)-4-(3-chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl 2,4-dimethylpiperazine-1-carboxylate Parent CAS No.[1626387-80-1] |
| 產(chǎn)品資料 |
