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產(chǎn)品名稱

BMS 540215 - Brivanib

產(chǎn)品貨號(hào)

Axon 1850 CAS [649735-46-6] MF C19H19FN4O3MW 370.38 Purity: 98% Optical purity: Optically pure Soluble in DMSO Description Potent and ATP-competitive inhibitor of VEGF; it inhibits VEGFR2, -1 and -3 with IC50 of 25, 380 and 10 nM respectively; also showed good selectivity for FGFR-1, -2, and -3 with IC50 of 148, 125 and 68 nM. BMS 540215 is the active component of its prodrug, Brivalib alaninate (BMS 582664, Axon 1864), which hydrolyzes to BMS 540215 in vivo quickly References Certificates Categories Extra info RS Bhide et al. Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor. J. Med. Chem. 2006, 49(7), 2143-2146.? ? ZW Cai et al. Discovery of brivanib alaninate ((S)-((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-yl)2-aminopropanoate), a novel prodrug of dual vascular (...). J. Med. Chem. 2008, 51(6), 1976-1980.? ? H Huynh et al. Brivanib Alaninate, a Dual Inhibitor of Vascular Endothelial Growth Factor Receptor and Fibroblast Growth Factor Receptor Tyrosine Kinases, Induces Growth Inhibition in Mouse Models (...). Clin. Cancer Res. 2008, 14, 6146.? Certificate of Analysis Material Safety Data Sheet Angiogenesis Cell Signaling & Oncology VEGFR RTK class IV; EC 2.7.10.1 Inhibitor of VEGFR (subtype 2 and 3 selective) Chemical name (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-yloxy)propan-2-ol Parent CAS No. [649735-46-6] Order Size Unit Price Stock 5 mg €110.00 In Stock

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

BMS 540215 - Brivanib

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 1850

CAS [649735-46-6]

MF C19H19FN4O3
MW 370.38

Purity: 98%
Optical purity: Optically pure
Soluble in DMSO

BMS 540215

Description

Potent and ATP-competitive inhibitor of VEGF; it inhibits VEGFR2, -1 and -3 with IC50 of 25, 380 and 10 nM respectively; also showed good selectivity for FGFR-1, -2, and -3 with IC50 of 148, 125 and 68 nM. BMS 540215 is the active component of its prodrug, Brivalib alaninate (BMS 582664, Axon 1864), which hydrolyzes to BMS 540215 in vivo quickly

RS Bhide et al. Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor. J. Med. Chem. 2006, 49(7), 2143-2146.?

ZW Cai et al. Discovery of brivanib alaninate ((S)-((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-yl)2-aminopropanoate), a novel prodrug of dual vascular (...). J. Med. Chem. 2008, 51(6), 1976-1980.?

H Huynh et al. Brivanib Alaninate, a Dual Inhibitor of Vascular Endothelial Growth Factor Receptor and Fibroblast Growth Factor Receptor Tyrosine Kinases, Induces Growth Inhibition in Mouse Models (...). Clin. Cancer Res. 2008, 14, 6146.?

Certificate of Analysis
Material Safety Data Sheet

Angiogenesis Cell Signaling & Oncology VEGFR RTK class IV; EC 2.7.10.1

Inhibitor of VEGFR (subtype 2 and 3 selective)

Chemical name

(R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-yloxy)propan-2-ol

Parent CAS No.

[649735-46-6]

產(chǎn)品資料

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