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產(chǎn)品名稱

Pelitinib - EKB 569

產(chǎn)品貨號

Axon 1665 CAS [257933-82-7 ] MF C24H23ClFN5O2MW 467.92 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description An irreversible inhibitor of EGFR tyrosine kinase with potential antineoplastic activity. Pelitinib irreversibly binds covalently to EGFR ErbB-1, -2 and -4, thereby inhibiting receptor phosphorylation and signal transduction and resulting in apoptosis and suppression of proliferation in tumor cells that overexpress these receptors References Certificates Categories Extra info M Nunes et al. Phosphorylation of extracellular signal-regulated kinase 1 and 2, protein kinase B, and signal transducer and activator of transcription 3 are differently inhibited by an EGFR inhibitor, EKB-569, (...). Mol. Cancer Ther. 2004, 3,21. ? C Erlichman et al. Phase I study of EKB-569, an irreversible inhibitor of the epidermal growth factor receptor, in patients with advanced solid tumors. J. Clin. Oncol. 2006, 24(15), 2252-2260. ? A Oca?a and E Amir. Irreversible pan-ErbB tyrosine kinase inhibitors and breast cancer: current status and future directions. Cancer Treat Rev. 2009, 5(8), 685-691. Certificate of Analysis Material Safety Data Sheet Angiogenesis Cell Signaling & Oncology EGFR JAK-STAT RTK class I; EC 2.7.10.1 EGFR tyrosine kinase inhibitor Chemical name (E)-N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide Parent CAS No. [257933-82-7 ] Order Size Unit Price Stock 5 mg €95.00 In Stock

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

Pelitinib - EKB 569

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 1665

CAS [257933-82-7 ]

MF C24H23ClFN5O2
MW 467.92

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

Pelitinib

Description

An irreversible inhibitor of EGFR tyrosine kinase with potential antineoplastic activity. Pelitinib irreversibly binds covalently to EGFR ErbB-1, -2 and -4, thereby inhibiting receptor phosphorylation and signal transduction and resulting in apoptosis and suppression of proliferation in tumor cells that overexpress these receptors

M Nunes et al. Phosphorylation of extracellular signal-regulated kinase 1 and 2, protein kinase B, and signal transducer and activator of transcription 3 are differently inhibited by an EGFR inhibitor, EKB-569, (...). Mol. Cancer Ther. 2004, 3,21.

C Erlichman et al. Phase I study of EKB-569, an irreversible inhibitor of the epidermal growth factor receptor, in patients with advanced solid tumors. J. Clin. Oncol. 2006, 24(15), 2252-2260.

A Oca?a and E Amir. Irreversible pan-ErbB tyrosine kinase inhibitors and breast cancer: current status and future directions. Cancer Treat Rev. 2009, 5(8), 685-691.

Certificate of Analysis
Material Safety Data Sheet

Angiogenesis Cell Signaling & Oncology EGFR JAK-STAT RTK class I; EC 2.7.10.1

EGFR tyrosine kinase inhibitor

Chemical name

(E)-N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide

Parent CAS No.

[257933-82-7 ]

產(chǎn)品資料

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