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產(chǎn)品名稱

TD52

產(chǎn)品貨號

Axon 2700 CAS [1798328-24-1] MF C24H16N4MW 360.41 Purity: 99% Soluble in DMSO Description The CIP2A inhibitor TD52 had more potent apoptotic effects than erlotinib (Axon 1128) in HCC cells (IC50 values of 0.9, 0.9, 0.8 and 1.2 μM in HA22T, Hep3B, PLC5 and Sk-Hep1 cell lines, respectively). Also, CIP2A-dependent p-Akt downregulation mediates TD52-induced apoptosis in TNBC. TD52-induced tumor inhibition was associated with reactivation of PP2A and downregulation of CIP2A and p-Akt in vivo. KEYWORDS: TD52 | supplier | CIP2A inhibitor | TD 52 | TD-52 | CAS [1798328-24-1] | PP2A | CIP2A | Inhibitor | Proteins | p90 | KIAA1524 | HCC | TNBC

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

TD52

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2700

CAS [1798328-24-1]

MF C24H16N4
MW 360.41

Purity: 99%
Soluble in DMSO

TD52

Description

The CIP2A inhibitor TD52 had more potent apoptotic effects than erlotinib (Axon 1128) in HCC cells (IC50 values of 0.9, 0.9, 0.8 and 1.2 μM in HA22T, Hep3B, PLC5 and Sk-Hep1 cell lines, respectively). Also, CIP2A-dependent p-Akt downregulation mediates TD52-induced apoptosis in TNBC. TD52-induced tumor inhibition was associated with reactivation of PP2A and downregulation of CIP2A and p-Akt in vivo.

KEYWORDS: TD52 | supplier | CIP2A inhibitor | TD 52 | TD-52 | CAS [1798328-24-1] | PP2A | CIP2A | Inhibitor | Proteins | p90 | KIAA1524 | HCC | TNBC

HC Yu et al. Erlotinib derivative inhibits hepatocellular carcinoma by targeting CIP2A to reactivate protein phosphatase 2A. Cell Death Dis. 2014 Jul 31;5:e1359.

CY Liu et al. EGFR-independent Elk1/CIP2A signalling mediates apoptotic effect of an erlotinib derivative TD52 in triple-negative breast cancer cells. Eur J Cancer. 2017 Feb;72:112-123.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology PI3K-Akt-mTOR CIP2A

CIP2A inhibitor; Erlotinib derivative

Chemical name

N2,N3-Bis(3-ethynylphenyl)quinoxaline-2,3-diamine

Parent CAS No.

[1798328-24-1]

產(chǎn)品資料

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