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產(chǎn)品名稱

CDDO - Bardoxolone | RTA 401

產(chǎn)品貨號

Axon 1950 CAS [218600-44-3] MF C31H41NO4MW 491.66 Purity: 98% Soluble in DMSO Description A potent multifunctional anti-tumor agent; CDDO induces apoptosis in vitro in malignant cells through both intrinsic and extrinsic pathways, and it controls cellular differentiation, apoptosis, and growth inhibition by serving as a ligand for the transcription factor PPAR-γ; highly active inhibitor of nitric oxide production in mouse macrophages; it shows antiinflammatory activity against thioglycollate-interferon-gamma-induced mouse peritonitis * Parent acid of CDDO-Me (Axon 1772) References Certificates Categories Extra info T Honda et al. Synthetic oleanane and ursane triterpenoids with modified rings A and C: a series of highly active inhibitors of nitric oxide production in mouse macrophages. J. Med. Chem. 2000, 43(22), 4233-4246.??? ? S Inoue et al. CDDO induces apoptosis via the intrinsic pathway in lymphoid cells. Leukemia 2004, 18(5), 948-952. ? K Liby et al. The Synthetic Triterpenoids, CDDO and CDDO-Imidazolide, Are Potent Inducers of Heme Oxygenase-1 and Nrf2/ARE Signaling. Cancer Res. 2005, 65(11), 4789-4798. ? SH Bernstein et al. The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives. Blood 2012, 119(14), 3321-3329. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Signaling & Oncology Stem Cell Differentiator PPAR NR1C A potent multifunctional anti-tumor agent. PPAR-γ agonist Chemical name (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylic acid Parent CAS No. [218600-44-3] Order Size Unit Price Stock 10 mg €110.00 In Stock

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

CDDO - Bardoxolone | RTA 401

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 1950

CAS [218600-44-3]

MF C31H41NO4
MW 491.66

Purity: 98%
Soluble in DMSO

CDDO

Description

A potent multifunctional anti-tumor agent; CDDO induces apoptosis in vitro in malignant cells through both intrinsic and extrinsic pathways, and it controls cellular differentiation, apoptosis, and growth inhibition by serving as a ligand for the transcription factor PPAR-γ; highly active inhibitor of nitric oxide production in mouse macrophages; it shows antiinflammatory activity against thioglycollate-interferon-gamma-induced mouse peritonitis

* Parent acid of CDDO-Me (Axon 1772)

T Honda et al. Synthetic oleanane and ursane triterpenoids with modified rings A and C: a series of highly active inhibitors of nitric oxide production in mouse macrophages. J. Med. Chem. 2000, 43(22), 4233-4246.???

S Inoue et al. CDDO induces apoptosis via the intrinsic pathway in lymphoid cells. Leukemia 2004, 18(5), 948-952.

K Liby et al. The Synthetic Triterpenoids, CDDO and CDDO-Imidazolide, Are Potent Inducers of Heme Oxygenase-1 and Nrf2/ARE Signaling. Cancer Res. 2005, 65(11), 4789-4798.

SH Bernstein et al. The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives. Blood 2012, 119(14), 3321-3329.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Signaling & Oncology Stem Cell Differentiator PPAR NR1C

A potent multifunctional anti-tumor agent. PPAR-γ agonist

Chemical name

(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylic acid

Parent CAS No.

[218600-44-3]

產(chǎn)品資料

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