<button id="eiezk"><video id="eiezk"></video></button>

產(chǎn)品名稱

CDDO-Me - Bardoxolone methyl | RTA 402

產(chǎn)品貨號

Axon 1772 CAS [218600-53-4] MF C32H43NO4MW 505.69 Purity: 98% Soluble in DMSO Description Orally-available antioxidant inflammation modulator (AIM), being the most potent known inducer of the Nrf2 pathway; induces apoptosis of human tumor cells by disruption of redox balance and directly blocks IKKβ activity and thereby the NF-κB pathway References Certificates Categories Extra info R Ahmad et al. Triterpenoid CDDO-Me Blocks the NF-κB Pathway by Direct Inhibition of IKKβ on Cys-179.?J. Biol. Chem. 2006,?281, 35764-35769. ? M Konopleva et al. Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia. Blood 2002, 99(1), 326-335. ? R Ahmad et al. Combining the FLT3 inhibitor PKC412 and the triterpenoid CDDO-Me synergistically induces apoptosis in acute myeloid leukemia with the internal tandem duplication mutation. Mol. Cancer Res. 2010, 8(7), 986-993. ? MB Sporn et al. New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress.?J. Nat. Prod. 2011, 74(3), 537-545. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Signaling & Oncology Immunology Pain & Inflammation Transcription Factors NF-κB EC 2.7.11.10 IKK IKK-2 inhibitor; Inducer of the Nrf2 pathway Chemical name (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-methyl 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate Parent CAS No. [218600-53-4] Order Size Unit Price Stock 5 mg €85.00 In Stock

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

CDDO-Me - Bardoxolone methyl | RTA 402

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 1772

CAS [218600-53-4]

MF C32H43NO4
MW 505.69

Purity: 98%
Soluble in DMSO

CDDO-Me

Description

Orally-available antioxidant inflammation modulator (AIM), being the most potent known inducer of the Nrf2 pathway; induces apoptosis of human tumor cells by disruption of redox balance and directly blocks IKKβ activity and thereby the NF-κB pathway

R Ahmad et al. Triterpenoid CDDO-Me Blocks the NF-κB Pathway by Direct Inhibition of IKKβ on Cys-179.?J. Biol. Chem. 2006,?281, 35764-35769.

M Konopleva et al. Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia. Blood 2002, 99(1), 326-335.

R Ahmad et al. Combining the FLT3 inhibitor PKC412 and the triterpenoid CDDO-Me synergistically induces apoptosis in acute myeloid leukemia with the internal tandem duplication mutation. Mol. Cancer Res. 2010, 8(7), 986-993.

MB Sporn et al. New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress.?J. Nat. Prod. 2011, 74(3), 537-545.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Signaling & Oncology Immunology Pain & Inflammation Transcription Factors NF-κB EC 2.7.11.10 IKK

IKK-2 inhibitor; Inducer of the Nrf2 pathway

Chemical name

(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-methyl 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate

Parent CAS No.

[218600-53-4]

產(chǎn)品資料

<button id="eiezk"><video id="eiezk"></video></button>