| 產(chǎn)品名稱 | FLI 06 |
| 產(chǎn)品貨號(hào) | Axon 2277 CAS [313967-18-9] MF C25H30N2O5MW 438.52 Purity: 100% Soluble in DMSO Description Notch signaling inhibitor (EC50 value 2.3 μM) that acts early in the secretory pathway. Although the precise molecular target of FLI 06 remains unclear, it effects a unique property to inhibit cargo recruitment to ER exit sites (ERESs) by changing its curvature. Consequently, it inhibits the membrane traffic of NotchΔE-eGFP at pre-ERES stages without fusion of ER-Golgi.FLI 06 does not inhibit the γ-secretase mediated proteolytical processing of NotchΔE-eGFP to NICD-eGFP at the plasma membrane. References Certificates Categories Extra info A. Kr?mer et al. Small molecules intercept Notch signaling and the early secretory pathway. Nat. Chem. Biol. 2013, 9, 731-738. Certificate of Analysis Material Safety Data Sheet Angiogenesis Cardiovascular CNS Epigenetics Stem Cell Endocrinology Unclassified ERES Golgi Notch signaling inhibitor that acts early in the secretory pathway Chemical name cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate Parent CAS No. [313967-18-9] Order Size Unit Price Stock 5 mg €95.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
FLI 06Axon 2277 CAS [313967-18-9] MF C25H30N2O5
Description
Notch signaling inhibitor (EC50 value 2.3 μM) that acts early in the secretory pathway. Although the precise molecular target of FLI 06 remains unclear, it effects a unique property to inhibit cargo recruitment to ER exit sites (ERESs) by changing its curvature. Consequently, it inhibits the membrane traffic of NotchΔE-eGFP at pre-ERES stages without fusion of ER-Golgi.FLI 06 does not inhibit the γ-secretase mediated proteolytical processing of NotchΔE-eGFP to NICD-eGFP at the plasma membrane.
Notch signaling inhibitor that acts early in the secretory pathway
Chemical namecyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate Parent CAS No.[313967-18-9] |
| 產(chǎn)品資料 |
