| 產(chǎn)品名稱 | Deltarasin trihydrochloride |
| 產(chǎn)品貨號 | Axon 2284 CAS [1440898-82-7] MF C40H37N5O.3HClMW 713.14 Purity: 99% Optical purity: Optically pure Soluble in water and DMSO Description Small molecule inhibitor of the KRAS–PDEδ interaction that impairs oncogenic KRAS signalling by altering its localization to endomembranes (in cell Kd value 41 nM for deltarasin binding to PDEδ). Deltarasin suppresses in vitro and in vivo MAPK signaling and proliferation of human pancreatic ductal adenocarcinoma (PDAC) cells that are dependent on oncogenic KRAS. References Certificates Categories Extra info G. Zimmermann et al.Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling. Nature 2013, 497, 638-642. ? B. Frett et al. Targeting the K-Ras/PDEδ Protein–Protein Interaction: The Solution for Ras-Driven Cancers or Just Another Therapeutic Mirage? ChemMedChem 2013, 8, 1620-1622. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology MAPK PDE Inhibitor of the prenyl binding protein PDEδ and the KRAS–PDEδ interaction. Chemical name (S)-1-benzyl-2-(4-(2-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(piperidin-4-yl)ethylphenyl-1H-benzo[d]imidazol-1-yl)-2-(piperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole trihydrochloride Parent CAS No. [1440898-61-2] Order Size Unit Price Stock 5 mg €115.00 In Stock |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
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| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
Deltarasin trihydrochlorideAxon 2284 CAS [1440898-82-7] MF C40H37N5O.3HCl
Description
Small molecule inhibitor of the KRAS–PDEδ interaction that impairs oncogenic KRAS signalling by altering its localization to endomembranes (in cell Kd value 41 nM for deltarasin binding to PDEδ). Deltarasin suppresses in vitro and in vivo MAPK signaling and proliferation of human pancreatic ductal adenocarcinoma (PDAC) cells that are dependent on oncogenic KRAS.
Inhibitor of the prenyl binding protein PDEδ and the KRAS–PDEδ interaction.
Chemical name(S)-1-benzyl-2-(4-(2-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(piperidin-4-yl)ethylphenyl-1H-benzo[d]imidazol-1-yl)-2-(piperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole trihydrochloride Parent CAS No.[1440898-61-2] |
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