| 產(chǎn)品名稱 | YMU1 |
| 產(chǎn)品貨號(hào) | Axon 2675 CAS [902589-96-2] MF C17H22N4O4SMW 378.45 Purity: 99% Soluble in DMSO Description Selective human thymidylate kinase (hTMPK; IC50 value 1.65 μM) inhibitor that lacks inhibitory effect on the activity of purified thymidine kinase 1 (TK1). YMU1 stabilizes the conformation of ligand-induced degradation (LID) region of hTMPK and blocks the catalytic site or ATP-binding site. Blocking hTMPK by YMU1 attenuates the ATP binding-induced closed conformation that is required for phosphorylation of dTMP, and sensitizes cancer cells for low-dose doxorubicin chemotherapy. Keywords: YMU1 | supplier | TMPK inhibtor | YMU-1 | YMU 1 | CAS [902589-96-2] | Thymidylate pathway | hTMPK | Phosphotransferase | dTTP | dTMP | doxorubicin | tuberculosis | cancer |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
YMU1Axon 2675 CAS [902589-96-2] MF C17H22N4O4S
DescriptionSelective human thymidylate kinase (hTMPK; IC50 value 1.65 μM) inhibitor that lacks inhibitory effect on the activity of purified thymidine kinase 1 (TK1). YMU1 stabilizes the conformation of ligand-induced degradation (LID) region of hTMPK and blocks the catalytic site or ATP-binding site. Blocking hTMPK by YMU1 attenuates the ATP binding-induced closed conformation that is required for phosphorylation of dTMP, and sensitizes cancer cells for low-dose doxorubicin chemotherapy. Keywords: YMU1 | supplier | TMPK inhibtor | YMU-1 | YMU 1 | CAS [902589-96-2] | Thymidylate pathway | hTMPK | Phosphotransferase | dTTP | dTMP | doxorubicin | tuberculosis | cancer
Selective inhibitor of human thymidylate kinase (hTMPK)
Chemical nameethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate Parent CAS No.[902589-96-2] |
| 產(chǎn)品資料 |
