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產(chǎn)品名稱

ZL006

產(chǎn)品貨號

Axon 2878 CAS [1181226-02-7] MF C14H11Cl2NO4MW 328.15 Purity: 99% Soluble in DMSO Description ZL006 blocked the ischemia-induced nNOS–PSD-95 association selectively, had potent neuroprotective activity in vitro and ameliorated focal cerebral ischemic damage in mice and rats subjected to middle cerebral artery occlusion (MCAO) and reperfusion. Moreover, it readily crossed the blood-brain barrier, did not inhibit NMDAR function, catalytic activity of nNOS or spatial memory, and had no effect on aggressive behaviors. KEYWORDS: ZL006 | supplier | nNOS-PSD-95 inhibitor | ZL 006 | ZL-006 | CAS [1181226-02-7] | Arginine,? L- | NOS | Inhibitor | Enzymes | Stroke | Cerebral ischemia | Nitric oxide synthase

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

ZL006

Based on 23 reference(s) in Google Scholar 8 10 23

Axon 2878

CAS [1181226-02-7]

MF C14H11Cl2NO4
MW 328.15

Purity: 99%
Soluble in DMSO

ZL006

Description

ZL006 blocked the ischemia-induced nNOS–PSD-95 association selectively, had potent neuroprotective activity in vitro and ameliorated focal cerebral ischemic damage in mice and rats subjected to middle cerebral artery occlusion (MCAO) and reperfusion. Moreover, it readily crossed the blood-brain barrier, did not inhibit NMDAR function, catalytic activity of nNOS or spatial memory, and had no effect on aggressive behaviors.

L Zhou et al. Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95. Nat Med. 2010 Dec;16(12):1439-43.

Certificate of Analysis
Material Safety Data Sheet

Cardiovascular Cell Signaling & Oncology CNS Pain & Inflammation Neuroprotectants NOS EC 1.14.13.39

Selective inhibitor of the nNOS-PSD-95 interaction

Chemical name

4-(3,5-Dichloro-2-hydroxybenzylamino)-2-hydroxybenzoic acid

Parent CAS No.

[1181226-02-7]

產(chǎn)品資料

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