<button id="eiezk"><video id="eiezk"></video></button>

產品名稱

STF 118804

產品貨號

Axon 2253 CAS [894187-61-2] MF C25H23N3O4SMW 461.53 Purity: 98% Soluble in DMSO Description Highly specific, next-generation NAMPT inhibitor, that reduces the viability of most B-ALL cell lines with high potency demonstrating IC50 values in the low nanomolar range, and improves survival in an orthotopic xenotransplant model of high-risk acute lymphoblastic leukemia. Additionally, STF 118804 induces leukemia cell apoptosis without antecedent cell cycle arrest, and targets leukemia stem cells. KEYWORDS:?STF 118804 | supplier | NAMPT inhibitor | STF118804 | CAS [894187-61-2] | Nicotinamide D-ribonucleotide | NAD | NAD+ | apoptosis | leukemia | cell cycle | arrest | stem cells

產品價格

現(xiàn)貨詢價，電話：010-67529703

產品規(guī)格

產品品牌

axonmedchem

產品概述

產品詳情

STF 118804

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2253

CAS [894187-61-2]

MF C25H23N3O4S
MW 461.53

Purity: 98%
Soluble in DMSO

STF 118804

Description

Highly specific, next-generation NAMPT inhibitor, that reduces the viability of most B-ALL cell lines with high potency demonstrating IC50 values in the low nanomolar range, and improves survival in an orthotopic xenotransplant model of high-risk acute lymphoblastic leukemia. Additionally, STF 118804 induces leukemia cell apoptosis without antecedent cell cycle arrest, and targets leukemia stem cells.

C.J. Matheny et al. Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem. Biol. 2013, 20, 1352-1363.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Signaling & Oncology Diabetes & Metabolism NAMPT EC 2.4.2.12

Highly specific, next-generation NAMPT inhibitor

Chemical name

4-(5-Methyl-4-(tosylmethyl)oxazol-2-yl)-N-(pyridin-3-ylmethyl)benzamide

Parent CAS No.

[894187-61-2]

產品資料

<button id="eiezk"><video id="eiezk"></video></button>