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產(chǎn)品名稱(chēng)

AZD 1208

產(chǎn)品貨號(hào)

Axon 2795 CAS [1204144-28-4] MF C21H21N3O2SMW 379.48 Purity: 98% Optical purity: optically pure Soluble in DMSO Description AZD 1208 is a pan-Pim kinase inhibitor (IC50 values of 0.4 nM, 5.0 nM and 1.9 nM for Pim-1, Pim-2 and Pim-3, respectively) which does not inhibit FLT3. AZD 1208 treatment resulted in growth inhibition and cell size reduction in AML cell lines including FLT3-WT (OCI-AML-3, KG-1a, MOLM-16) and FLT3-ITD mutated (MOLM-13, MV-4-11). KEYWORDS: AZD 1208 | supplier | PIM inhibitor | AZD1208 | AZD-1208 | CAS [1204144-28-4] | Non Selective (Phosphorylation Substrates) | PIM | Inhibitor | Enzymes | AML

產(chǎn)品價(jià)格

現(xiàn)貨詢(xún)價(jià)，電話(huà)：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

AZD 1208

Based on 28 reference(s) in Google Scholar 8 10 28

Axon 2795

CAS [1204144-28-4]

MF C21H21N3O2S
MW 379.48

Purity: 98%
Optical purity: optically pure
Soluble in DMSO

AZD 1208

Description

AZD 1208 is a pan-Pim kinase inhibitor (IC50 values of 0.4 nM, 5.0 nM and 1.9 nM for Pim-1, Pim-2 and Pim-3, respectively) which does not inhibit FLT3. AZD 1208 treatment resulted in growth inhibition and cell size reduction in AML cell lines including FLT3-WT (OCI-AML-3, KG-1a, MOLM-16) and FLT3-ITD mutated (MOLM-13, MV-4-11).

KEYWORDS: AZD 1208 | supplier | PIM inhibitor | AZD1208 | AZD-1208 | CAS [1204144-28-4] | Non Selective (Phosphorylation Substrates) | PIM | Inhibitor | Enzymes | AML

LA Dakin et al. Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4599-604.

LS Chen et al. Protein profiling identifies mTOR pathway modulation and cytostatic effects of Pim kinase inhibitor, AZD1208, in acute myeloid leukemia. Leuk Lymphoma. 2016 Dec;57(12):2863-2873.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Epigenetics Immunology JAK-STAT EC 2.7.11.1 PIM

Pim kinase inhibitor

Chemical name

(R,Z)-5-((2-(3-Aminopiperidin-1-yl)biphenyl-3-yl)methylene)thiazolidine-2,4-dione

Parent CAS No.

[1204144-28-4]

產(chǎn)品資料

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