| 產(chǎn)品名稱 | ONO 5334 |
| 產(chǎn)品貨號 | Axon 2156 CAS [868273-90-9] MF C21H34N4O4SMW 438.58 Purity: 98% Optical purity: Optically pure Soluble in DMSO Description Potent and orally available inhibitor of cathepsin K (Ki values of 0.1 nM, 0.049 nM and 0.85 nM for human, rabbit and rat respectively). ONO 5334 dose depedently suppresses human osteoclast-mediated bone resorption in vitro, and reduced PTHrP-induced increase in plasma calcium with significant effect (86% reduction) after oral administration in TPTX pretreated rats. References Certificates Categories Extra info R. Eastell et al. Effect of ONO-5334 on Bone Mineral Density and Biochemical Markers of Bone Turnover in Postmenopausal Osteoporosis: 2-Year Results From the OCEAN Study. J. Bone Miner Res. 2014, 29, 458-466.? ? Y. Ochi et al. Effects of ONO-5334, a novel orally-active inhibitor of cathepsin K, on bone metabolism. Bone. 2011, 49, 1351-1356.? Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Miscellaneous Cathepsin-K EC 3.4.22.8 Potent and orally available inhibitor of cathepsin K Chemical name N-((R)-3-((Z)-2-((R)-3,4-dimethylthiazolidin-2-ylidene)hydrazinyl)-2,3-dioxo-1-(tetrahydro-2H-pyran-4-yl)propyl)cycloheptanecarboxamide Parent CAS No. [868273-90-9] Order Size Unit Price Stock 2 mg €110.00 In Stock |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
ONO 5334Axon 2156 CAS [868273-90-9] MF C21H34N4O4S
Description
Potent and orally available inhibitor of cathepsin K (Ki values of 0.1 nM, 0.049 nM and 0.85 nM for human, rabbit and rat respectively). ONO 5334 dose depedently suppresses human osteoclast-mediated bone resorption in vitro, and reduced PTHrP-induced increase in plasma calcium with significant effect (86% reduction) after oral administration in TPTX pretreated rats.
Potent and orally available inhibitor of cathepsin K
Chemical nameN-((R)-3-((Z)-2-((R)-3,4-dimethylthiazolidin-2-ylidene)hydrazinyl)-2,3-dioxo-1-(tetrahydro-2H-pyran-4-yl)propyl)cycloheptanecarboxamide Parent CAS No.[868273-90-9] |
| 產(chǎn)品資料 |
