| 產(chǎn)品名稱 | CBR 5884 |
| 產(chǎn)品貨號 | Axon 2585 CAS [681159-27-3] MF C14H12N2O4S2MW 336.39 Purity: 99% Soluble in DMSO Description Noncompetitive inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH; IC50 value 33 μM) with selective toxicity towards cancer cell lines with high serine biosynthetic activity. CBR-5884 shows no inhibitory effect on two other NAD+-dependent dehydrogenases, lactate dehydrogenase (LDH) and MDH1A. A useful tool to study the biology of de novo serine synthesis enabling preclinical evaluation of PHGDH as a target in cancer. KEYWORDS:?CBR 5884 | supplier | PHGDH inhibitor | CBR5884 | CAS [681159-27-3] | 3-phosphoglycerate | PHGDH | dehydrogenase | breast | cancer | serine biosynthesis | NAD+ dependent |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
CBR 5884Axon 2585 CAS [681159-27-3] MF C14H12N2O4S2
DescriptionNoncompetitive inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH; IC50 value 33 μM) with selective toxicity towards cancer cell lines with high serine biosynthetic activity. CBR-5884 shows no inhibitory effect on two other NAD+-dependent dehydrogenases, lactate dehydrogenase (LDH) and MDH1A. A useful tool to study the biology of de novo serine synthesis enabling preclinical evaluation of PHGDH as a target in cancer. KEYWORDS:?CBR 5884 | supplier | PHGDH inhibitor | CBR5884 | CAS [681159-27-3] | 3-phosphoglycerate | PHGDH | dehydrogenase | breast | cancer | serine biosynthesis | NAD+ dependent
Noncompetitive inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH)
Chemical nameethyl 5-(furan-2-carboxamido)-3-methyl-4-thiocyanatothiophene-2-carboxylate Parent CAS No.[681159-27-3] |
| 產(chǎn)品資料 |
