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產(chǎn)品名稱

BTZ043

產(chǎn)品貨號

Axon 2698 CAS [1161233-85-7] MF C17H16F3N3O5SMW 431.39 Purity: 100% Optical purity: Optically pure Soluble in DMSO Description Antimycobacterial agent that kills Mycobacterium tuberculosis (MIC values 2.3 nM and 9.2 nM against M. tuberculosis H37Rv and M. smegmatis, respectively) in vitro, ex vivo, and in mouse models of TB through inhibition of decaprenylphosphoryl-b-D-ribose 2′-epimerase (DprE1). KEYWORDS: BTZ043 | supplier | DprE1 inhibitor | BTZ-043 | BTZ 043 | BTZ-10526043 | BTZ 10526043 | CAS [1161233-85-7] | Decaprenylphosphoryl-beta-D-ribofuranose (DPR) | DprE | Inhibitor | Enzymes

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

BTZ043

Based on 47 publications in PubMed 10 10 47

Axon 2698

CAS [1161233-85-7]

MF C17H16F3N3O5S
MW 431.39

Purity: 100%
Optical purity: Optically pure
Soluble in DMSO

BTZ043

Description

Antimycobacterial agent that kills Mycobacterium tuberculosis (MIC values 2.3 nM and 9.2 nM against M. tuberculosis H37Rv and M. smegmatis, respectively) in vitro, ex vivo, and in mouse models of TB through inhibition of decaprenylphosphoryl-b-D-ribose 2′-epimerase (DprE1).

KEYWORDS: BTZ043 | supplier | DprE1 inhibitor | BTZ-043 | BTZ 043 | BTZ-10526043 | BTZ 10526043 | CAS [1161233-85-7] | Decaprenylphosphoryl-beta-D-ribofuranose (DPR) | DprE | Inhibitor | Enzymes

V Makarov. Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis. Science. 2009 May 8;324(5928):801-4.

C Trefzer et al. Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-β-D-ribofuranose 2'-oxidase DprE1. J Am Chem Soc. 2012 Jan 18;134(2):912-5.

SM Batt et al. Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11354-9.

Certificate of Analysis
Material Safety Data Sheet

Immunology DprE EC 1.1.98.3

Antimycobacterial DprE1 inhibitor that kills Mycobacterium tuberculosis

Chemical name

(S)-2-(2-Methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-8-nitro-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one

Parent CAS No.

[1161233-85-7]

產(chǎn)品資料

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