| 產(chǎn)品名稱 | Thioridazine hydrochloride |
| 產(chǎn)品貨號 | Axon 2193 CAS [130-61-0] MF C21H26N2S2.HClMW 407.04 Purity: 99% Soluble in water and DMSO Description Antipsychotic with (sub-) nanomolar affinity for dopamine and α-adrenergic receptors (Ki of 0.4 nM, 1.5 nM, 1.5 nM, 3.2 nM, 2.4 nM for D2, D3, D4, α1A, and α1B resp.). Recently, Thioridazine was found to inhibit full length recombinant MALT1 (IC50 3.43 μM). It inhibits anti-apoptotic NF-κB signaling and elicits toxic effects selectively on MALT1-dependent ABC-DLBCL cells. Additionally, it suppresses tumor growth activity by targeting the PI3K/Akt/mTOR/p70S6K signaling pathway. References Certificates Categories Extra info D. Nagel et al. Pharmacologic Inhibition of MALT1 Protease by Phenothiazines as a Therapeutic Approach for the Treatment of Aggressive ABC-DLBCL. Canc. Cell 2012, 22, 825–837.? ? S. Kang et al. Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells. Apoptosis. 2012, 17, 989–997. ? RM Young?& LM Staudt. A New “Brew” of MALT1 Inhibitors. Cancer Cell, 2012, 22(6), 706-707.? ? DJ Burgess. Anticancer drugs: Assault on MALT1. Nature Reviews Drug Discovery, 2013, 12(2), 100-101.? Certificate of Analysis Material Safety Data Sheet Apoptosis CNS D2 D3 D4 Adrenoceptor α1 MALT1 NF-κB PI3K-Akt-mTOR EC 3.4.22 Stem Cell Differentiator DA and α1 adrenoceptor antagonist; MALT1 inhibitor Chemical name 10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine hydrochloride Parent CAS No. [50-52-2] Order Size Unit Price Stock 10 mg €50.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
Thioridazine hydrochlorideAxon 2193 CAS [130-61-0] MF C21H26N2S2.HCl
DescriptionAntipsychotic with (sub-) nanomolar affinity for dopamine and α-adrenergic receptors (Ki of 0.4 nM, 1.5 nM, 1.5 nM, 3.2 nM, 2.4 nM for D2, D3, D4, α1A, and α1B resp.). Recently, Thioridazine was found to inhibit full length recombinant MALT1 (IC50 3.43 μM). It inhibits anti-apoptotic NF-κB signaling and elicits toxic effects selectively on MALT1-dependent ABC-DLBCL cells. Additionally, it suppresses tumor growth activity by targeting the PI3K/Akt/mTOR/p70S6K signaling pathway.
DA and α1 adrenoceptor antagonist; MALT1 inhibitor
Chemical name10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine hydrochloride Parent CAS No.[50-52-2] |
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