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產(chǎn)品名稱

Cambinol - NSC 112546

產(chǎn)品貨號(hào)

Axon 2803 CAS [14513-15-6] MF C21H16N2O2SMW 360.43 Purity: 99% Soluble in DMSO Description Cambinol inhibits NAD-dependent deacetylase activity of human SIRT1 and SIRT2 (IC50 values of 56 and 59 μM, respectively). Consistent with the role of SIRT1 in promoting cell survival during stress, inhibition of SIRT1 activity with cambinol during genotoxic stress leads to hyperacetylation of key stress response proteins and promotes cell cycle arrest. Cambinol exerts antitumor activity in vitro and in mouse xenograft studies. Moreover, cambinol is an uncompetitive nSMase2 inhibitor (Ki value of 7 μM). KEYWORDS: Cambinol | supplier | SIRT inhibitor | NSC 112546 | NSC112546 | NSC-112546 | CAS [14513-15-6] | Histone | SIRT | Inhibitor | Enzymes | nSMase2

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

Cambinol - NSC 112546

Based on 25 reference(s) in Google Scholar 8 10 25

Axon 2803

CAS [14513-15-6]

MF C21H16N2O2S
MW 360.43

Purity: 99%
Soluble in DMSO

Cambinol

Description

Cambinol inhibits NAD-dependent deacetylase activity of human SIRT1 and SIRT2 (IC50 values of 56 and 59 μM, respectively). Consistent with the role of SIRT1 in promoting cell survival during stress, inhibition of SIRT1 activity with cambinol during genotoxic stress leads to hyperacetylation of key stress response proteins and promotes cell cycle arrest. Cambinol exerts antitumor activity in vitro and in mouse xenograft studies. Moreover, cambinol is an uncompetitive nSMase2 inhibitor (Ki value of 7 μM).

B Heltweg et al. Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res. 2006 Apr 15;66(8):4368-77.

M Figuera-Losada et al. Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties. PLoS One. 2015 May 26;10(5):e0124481.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology CNS Diabetes & Metabolism Epigenetics DNA-damage Response EC 3.5.1.98 SIRT

Inhibitor of SIRT1 and SIRT2

Chemical name

5-((2-Hydroxynaphthalen-1-yl)methyl)-6-phenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

Parent CAS No.

[14513-15-6]

產(chǎn)品資料

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