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產(chǎn)品名稱(chēng)

4BP-TQS

產(chǎn)品貨號(hào)

Axon 2694 CAS [360791-49-7] MF C18H17BrN2O2SMW 405.31 Purity: 99% Soluble in DMSO Description 4BP-TQS is an allosteric agonist of α7 nicotinic acetylcholine receptors (nAChR). The agonism was shown to act through a site topographically distinct from the ACh site. 4BP-TQS was a more potent and efficacious agonist of α7 nAChR than ACh (8-fold lower EC50 and 45-fold larger maximal response). The bioactive enantiomer of 4BP-TQS, GAT107 (Axon 2621), is also available. KEYWORDS: 4BP-TQS | supplier | α7 nAChR allosteric agonist | 4BPTQS | 4-BPTQS | 4-BP-TQS | CAS [360791-49-7] | Acetylcholine | nAChR | Allosteric agonist | Ion Channels | CAS [1476053-27-6]

產(chǎn)品價(jià)格

現(xiàn)貨詢(xún)價(jià)，電話(huà)：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

4BP-TQS

Based on 4 reference(s) in Google Scholar 8 10 4

Axon 2694

CAS [360791-49-7]

MF C18H17BrN2O2S
MW 405.31

Purity: 99%
Soluble in DMSO

4BP-TQS

Description

4BP-TQS is an allosteric agonist of α7 nicotinic acetylcholine receptors (nAChR). The agonism was shown to act through a site topographically distinct from the ACh site. 4BP-TQS was a more potent and efficacious agonist of α7 nAChR than ACh (8-fold lower EC50 and 45-fold larger maximal response).

The bioactive enantiomer of 4BP-TQS, GAT107 (Axon 2621), is also available.

JK Gill et al. Agonist activation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site. Proc Natl Acad Sci USA. 2011 Apr 5;108(14):5867-72.

RL Papke. The activity of GAT107, an allosteric activator and positive modulator of α7 nicotinic acetylcholine receptors (nAChR), is regulated by aromatic amino acids that span the subunit interface. J Biol Chem. 2014 Feb 14;289(7):4515-31.

Certificate of Analysis
Material Safety Data Sheet

CNS Pain & Inflammation nAChR Unclassified

Allosteric agonist of α7 nAChR

Chemical name

4-(4-Bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide

Parent CAS No.

[360791-49-7]

產(chǎn)品資料

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