| 產(chǎn)品名稱 | A 804598 |
| 產(chǎn)品貨號(hào) | Axon 2182 CAS [1125758-85-1] MF C19H17N5MW 315.37 Purity: 99% Optical purity: >99% e.e. Soluble in DMSO Description Potent and selective P2X7 antagonist (IC50 values 10 nM, 9 nM, and 11 nM for rat, mouse, and human receptors respectively). A 804598 potently blocked agonist stimulated release of IL-1β and Yo-Pro uptake from differentiated THP-1 cells that natively express human P2X7 receptors.In another study, A 804598 was found to produce a concentration-dependent inhibition of BZ-ATP-stimulated calcium influx (IC50 value 28.71 nM) in cells expressing the rat recombinant P2X7 receptor; a useful tool for autoradiographic localization of P2X7 receptors in the rat brain and spinal cord. References Certificates Categories Extra info D.L. Donnelly-Roberts et al. [3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors. Neuropharm. 2009, 56, 223–229. S.L. Able et al. Receptor localization, native tissue binding and ex vivo occupancy for centrally penetrant P2X7 antagonists in the rat. Br. J. Pharmacol. 2011, 162, 405–414.? Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Signaling & Oncology CNS Pain & Inflammation P2X7 Unclassified Potent and selective P2X7 antagonist Chemical name (S)-2-cyano-1-(1-phenylethyl)-3-(quinolin-5-yl)guanidine Parent CAS No. [1125758-85-1] Order Size Unit Price Stock 10 mg €125.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
A 804598Axon 2182 CAS [1125758-85-1] MF C19H17N5
Description
Potent and selective P2X7 antagonist (IC50 values 10 nM, 9 nM, and 11 nM for rat, mouse, and human receptors respectively). A 804598 potently blocked agonist stimulated release of IL-1β and Yo-Pro uptake from differentiated THP-1 cells that natively express human P2X7 receptors.In another study, A 804598 was found to produce a concentration-dependent inhibition of BZ-ATP-stimulated calcium influx (IC50 value 28.71 nM) in cells expressing the rat recombinant P2X7 receptor; a useful tool for autoradiographic localization of P2X7 receptors in the rat brain and spinal cord.
Potent and selective P2X7 antagonist
Chemical name(S)-2-cyano-1-(1-phenylethyl)-3-(quinolin-5-yl)guanidine Parent CAS No.[1125758-85-1] |
| 產(chǎn)品資料 |
