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產(chǎn)品名稱

JNJ 47965567

產(chǎn)品貨號(hào)

Axon 2890 CAS [1428327-31-4] MF C28H32N4O2SMW 488.64 Purity: 99% Soluble in DMSO Description Highly potent and brain penetrant P2X7 antagonist in human, rat, and mouse cell lines (pKi values of 7.9, 7.9 and 6.9 for human, rat, and human whole blood P2X7). Probe compound for the preclinical assessment of P2X7 blockade in animal models of neuro-inflammation. DMPK properties suitable for preclinical pharmacodynamics studies. Keywords: JNJ 47965567 | supplier | P2X7 antagonist | JNJ47965567 | JNJ-47965567 | CAS [1428327-31-4] | Non Selective (Cations) | P2X7 | Antagonist | Ion Channels | Brain Penetrant | Neuro-inflammation

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

JNJ 47965567

Based on 6 reference(s) in Google Scholar 8 10 6

Axon 2890

CAS [1428327-31-4]

MF C28H32N4O2S
MW 488.64

Purity: 99%
Soluble in DMSO

JNJ 47965567

Description

Highly potent and brain penetrant P2X7 antagonist in human, rat, and mouse cell lines (pKi values of 7.9, 7.9 and 6.9 for human, rat, and human whole blood P2X7). Probe compound for the preclinical assessment of P2X7 blockade in animal models of neuro-inflammation. DMPK properties suitable for preclinical pharmacodynamics studies.

MA Letavic et al. Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X7 Antagonists. ACS Med Chem Lett. 2013 Mar 12;4(4):419-22.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Signaling & Oncology CNS Pain & Inflammation P2X7 Unclassified

Potent, brain-penetrant P2X7 antagonist

Chemical name

N-((4-(4-Phenylpiperazin-1-yl)tetrahydro-2H-pyran-4-yl)methyl)-2-(phenylthio)nicotinamide

Parent CAS No.

[1428327-31-4]

產(chǎn)品資料

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