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產(chǎn)品名稱

ZQ-16

產(chǎn)品貨號

Axon 2616 CAS [376616-73-8] MF C10H16N2O2SMW 228.31 Purity: 99% Soluble in DMSO and Ethanol Description Potent and selective small-molecule GPR84 agonist (EC50 value 0.139 μM in a calcium mobilization assay). ZQ-16 induced phosphorylation of ERK1/2, and a dose-dependent reduction of forskolin-stimulated cAMP accumulation in HEK293 cells expressing GPR84. KEYWORDS:?ZQ-16 | supplier | GPR84 agonist | ZQ16 | CAS [376616-73-8] | FFA | GPR84 | GPCR | free fatty acids | ERK1 | ERK3 | inflammation | immunology | cAMP

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

ZQ-16

Based on 2 publications in PubMed 8 10 2

Axon 2616

CAS [376616-73-8]

MF C10H16N2O2S
MW 228.31

Purity: 99%
Soluble in DMSO and Ethanol

ZQ-16

Description

Potent and selective small-molecule GPR84 agonist (EC50 value 0.139 μM in a calcium mobilization assay). ZQ-16 induced phosphorylation of ERK1/2, and a dose-dependent reduction of forskolin-stimulated cAMP accumulation in HEK293 cells expressing GPR84.

KEYWORDS:?ZQ-16 | supplier | GPR84 agonist | ZQ16 | CAS [376616-73-8] | FFA | GPR84 | GPCR | free fatty acids | ERK1 | ERK3 | inflammation | immunology | cAMP

Q Zhang et al. Discovery and Characterization of a Novel Small-Molecule Agonist for Medium-Chain Free Fatty Acid Receptor G Protein-Coupled Receptor 84. J Pharmacol Exp Ther. 2016 May;357(2):337-44.

Y Liu et al. Design and Synthesis of 2-Alkylpyrimidine-4,6-diol and 6-Alkylpyridine-2,4-diol as Potent GPR84 Agonists. ACS Med Chem Lett. 2016 Mar 30;7(6):579-83.

Certificate of Analysis
Material Safety Data Sheet

CNS Immunology Pain & Inflammation A18 GPR84

Potent and selective GPR84 agonist that induces phosphorylation of ERK1/2

Chemical name

2-(hexylthio)pyrimidine-4,6-diol

Parent CAS No.

[376616-73-8]

產(chǎn)品資料

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