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產(chǎn)品名稱

Calhex 231 hydrochloride

產(chǎn)品貨號

Axon 1818 CAS [N.A.] MF C25H27ClN2O.HClMW 443.41 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description Negative allosteric modulator (NAM) of the extracellular Calcium-sensing receptor (CaSR or CaR); inhibit Ca2+-induced accumulation of [3H]inositol phosphates in HEK293 cells (IC50: 0.39 microm) References Certificates Categories Extra info C Petrel et al. Modeling and mutagenesis of the binding site of Calhex 231, a novel negative allosteric modulator of the extracellular Ca(2+)-sensing receptor.?J. Biol. Chem. 2003, 278(49), 49487-49494. ? A Kessler et al. N1-Benzoyl-N2-[1-(1-naphthyl)ethyl]-trans-1,2-diaminocyclohexanes: Development of 4-chlorophenylcarboxamide (calhex 231) as a new calcium sensing receptor ligand (...). J. Med. Chem. 2006, 49(17), 5119-5128.? Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology CNS CaSR C1 NAM of the extracellular CaSR Chemical name 4-chloro-N-((1S,2S)-2-((R)-1-(naphthalen-1-yl)ethylamino)cyclohexyl)benzamide hydrochloride Parent CAS No. [652973-93-8] Order Size Unit Price Stock 5 mg €99.00 In Stock

產(chǎn)品價格

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產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

Calhex 231 hydrochloride

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 1818

CAS [N.A.]

MF C25H27ClN2O.HCl
MW 443.41

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

Calhex 231 hydrochloride

Description

Negative allosteric modulator (NAM) of the extracellular Calcium-sensing receptor (CaSR or CaR); inhibit Ca2+-induced accumulation of [3H]inositol phosphates in HEK293 cells (IC50: 0.39 microm)

C Petrel et al. Modeling and mutagenesis of the binding site of Calhex 231, a novel negative allosteric modulator of the extracellular Ca(2+)-sensing receptor.?J. Biol. Chem. 2003, 278(49), 49487-49494.

A Kessler et al. N1-Benzoyl-N2-[1-(1-naphthyl)ethyl]-trans-1,2-diaminocyclohexanes: Development of 4-chlorophenylcarboxamide (calhex 231) as a new calcium sensing receptor ligand (...). J. Med. Chem. 2006, 49(17), 5119-5128.?

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology CNS CaSR C1

NAM of the extracellular CaSR

Chemical name

4-chloro-N-((1S,2S)-2-((R)-1-(naphthalen-1-yl)ethylamino)cyclohexyl)benzamide hydrochloride

Parent CAS No.

[652973-93-8]

產(chǎn)品資料

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