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產(chǎn)品名稱

APD 597 - JNJ 38431055

產(chǎn)品貨號

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

APD 597 - JNJ 38431055

Based on 51 reference(s) in Google Scholar 9 10 51

Axon 2541

CAS [897732-93-3]

MF C21H29N5O6S
MW 479.55

Purity: 99%
Soluble in DMSO

APD 597

Description

Orally bioavailable selective GPR119 agonist (EC50 value 44 nM for hGPR119, IC50 value 13 μM) with a good balance between agonist potency, intrinsic activity, metabolic profile and in particular on its good solubility and reduced drug–drug interaction potential. In clinical trial, JNJ 38431055 was well tolerated and not associated with hypoglycaemia.

G. Semple et al. Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1750-5.

L.B. Katz et al. Pharmacokinetics, pharmacodynamics, safety, and tolerability of JNJ-38431055, a novel GPR119 receptor agonist and potential antidiabetes agent, in healthy male subjects. Clin Pharmacol Ther. 2011 Nov;90(5):685-92.

L.B. Katz et al. Effects of JNJ-38431055, a novel GPR119 receptor agonist, in randomized, double-blind, placebo-controlled studies in subjects with type 2 diabetes. Diabetes Obes Metab. 2012 Aug;14(8):709-16.

Certificate of Analysis
Material Safety Data Sheet

CNS Diabetes & Metabolism Endocrinology GPR119 A15

Orally bioavailable selective GPR119 agonist

Chemical name

isopropyl 4-(5-methoxy-6-(2-methyl-6-(methylsulfonyl)pyridin-3-ylamino)pyrimidin-4-yloxy)piperidine-1-carboxylate

Parent CAS No.

[897732-93-3]

產(chǎn)品資料

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