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產(chǎn)品名稱

BETP - Compound B

產(chǎn)品貨號(hào)

Axon 2259 CAS [1371569-69-5] MF C20H17F3N2O2SMW 406.42 Purity: 99% Soluble in DMSO Description Positive allosteric modulator (PAM) at the glucagon-like peptide 1 receptor (GLP-1; EC50 value 0.66 μM) with good selectivity over GLP-2, GIP, PTH, and glucagon receptors. BETP has a signifficant effect on cAMP accumulation, iCa2+ mobilization, and β-arrestin1 and β-arrestin2 recruitment in Flp-In-CHO cells stably expressing the human GLP-1R (pEC50 values 5.2, 5, 5.0, and 5.0, respectively). BETP induced glucose-dependent insulin secretion in vitro and in vivo, and increased calcium influx in CHO cells expressing GLP-1R. References Certificates Categories Extra info D. Wootten et al. Differential activation and modulation of the glucagon-like peptide-1 receptor by small molecule ligands. Mol. Pharmacol. 2013, 83, 822-834. ? F.S. Willard et al. Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin. Mol. Pharmacol. 2012, 82, 1066-10673. ? Y.H. Cheong et al. Two small molecule agonists of glucagon-like peptide-1 receptor modulate the receptor activation response differently. Biochem. Biophys. Res. Commun. 2012, 417, 558-563. ? K.W. Sloop et al. Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human islets. Diabetes. 2010, 59, 3099-3107. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Diabetes & Metabolism Endocrinology GLP-1 B1 Positive allosteric modulator (PAM) at the GLP-1 receptor Chemical name 4-(3-(benzyloxy)phenyl)-2-(ethylsulfinyl)-6-(trifluoromethyl)pyrimidine Parent CAS No. [1371569-69-5] Order Size Unit Price Stock 10 mg €105.00 In Stock

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產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

BETP - Compound B

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2259

CAS [1371569-69-5]

MF C20H17F3N2O2S
MW 406.42

Purity: 99%
Soluble in DMSO

BETP

Description

Positive allosteric modulator (PAM) at the glucagon-like peptide 1 receptor (GLP-1; EC50 value 0.66 μM) with good selectivity over GLP-2, GIP, PTH, and glucagon receptors. BETP has a signifficant effect on cAMP accumulation, iCa2+ mobilization, and β-arrestin1 and β-arrestin2 recruitment in Flp-In-CHO cells stably expressing the human GLP-1R (pEC50 values 5.2, 5, 5.0, and 5.0, respectively). BETP induced glucose-dependent insulin secretion in vitro and in vivo, and increased calcium influx in CHO cells expressing GLP-1R.

D. Wootten et al. Differential activation and modulation of the glucagon-like peptide-1 receptor by small molecule ligands. Mol. Pharmacol. 2013, 83, 822-834.

F.S. Willard et al. Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin. Mol. Pharmacol. 2012, 82, 1066-10673.

Y.H. Cheong et al. Two small molecule agonists of glucagon-like peptide-1 receptor modulate the receptor activation response differently. Biochem. Biophys. Res. Commun. 2012, 417, 558-563.

K.W. Sloop et al. Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human islets. Diabetes. 2010, 59, 3099-3107.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology Diabetes & Metabolism Endocrinology GLP-1 B1

Positive allosteric modulator (PAM) at the GLP-1 receptor

Chemical name

4-(3-(benzyloxy)phenyl)-2-(ethylsulfinyl)-6-(trifluoromethyl)pyrimidine

Parent CAS No.

[1371569-69-5]

產(chǎn)品資料

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