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產(chǎn)品名稱

TCS1102

產(chǎn)品貨號

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

TCS1102

Based on 11 reference(s) in Google Scholar 8 10 11

Axon 2744

CAS [916141-36-1]

MF C27H26N4O2S
MW 470.59

Purity: 98%
Optical purity: Optically pure
Soluble in DMSO

TCS1102

Description

TCS1102 is a potent and selective dual orexin receptor antagonist (Ki values of 3 and 0.2 nM for hOX1R and hOX2R, respectively). Moreover, TCS1102 demonstrated in vivo central activity when dosed peripherally in a pharmacodynamic model of orexin activity.

JM Bergman et al. Proline bis-amides as potent dual orexin receptor antagonists. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1425-30.

CJ Winrow et al. Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure. Neuropharmacology. 2010 Jan;58(1):185-94.

SY Khoo et al. The dual orexin receptor antagonist TCS1102 does not affect reinstatement of nicotine-seeking. PLoS One. 2017 Mar 15;12(3):e0173967.

Certificate of Analysis
Material Safety Data Sheet

CNS A6 Orexin (OX)

Dual orexin (OX1/2) receptor antagonist

Chemical name

(S)-N-(Biphenyl-2-yl)-1-(2-(1-methyl-1H-benzo[d]imidazol-2-ylthio)acetyl)pyrrolidine-2-carboxamide

Parent CAS No.

[916141-36-1]

產(chǎn)品資料

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