| 產(chǎn)品名稱 | Hydroxybuspirone hydrochloride, (R)-6- - BMS 442608 hydrochloride |
| 產(chǎn)品貨號(hào) | Axon 1997 CAS [N.A.] MF C21H31N5O3.HClMW 437.96 Purity: 99% Soluble in water and DMSO Description Optically pure (R)-enantiomer of 6-hydroxybuspirone (Axon 1996), a major active metabolite of Buspirone (Axon 1995); 5-HT1A partial agonist. (R)-Enantiomer showed higher affinity and selectivity for the 5HT1A receptor compared to the (S)-enantiomer; while (S)-Enantiomer has advantage of being cleared more slowly from blood compared to the (R)-enantiomer References Certificates Categories Extra info H Wong et al. 6-Hydroxybuspirone is a major active metabolite of buspirone: assessment of pharmacokinetics and 5-hydroxytryptamine1A receptor occupancy in rats. Drug Metab. Dispos. 2007, 35(8), 1387-1392.? ? RC Dockens et al. Pharmacokinetics of 6-hydroxybuspirone and its enantiomers administered individually or following buspirone administration in humans. Biopharm. Drug Dispos. 2007, 28(7), 393-402.? ? SJ Nicholson et al. Development of oral extended release formulations of 6-hydroxybuspirone. Biopharm. Drug Dispos. 2012, 33(9), 522-535.? Certificate of Analysis Material Safety Data Sheet CNS 5-HT1A A19 5-HT1A partial agonist Chemical name (R)-6-hydroxy-8-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)-8-azaspiro[4.5]decane-7,9-dione hydrochloride Parent CAS No. [477930-30-6] Order Size Unit Price Stock 1 mg €105.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
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| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
Hydroxybuspirone hydrochloride, (R)-6- - BMS 442608 hydrochlorideAxon 1997 CAS [N.A.] MF C21H31N5O3.HCl
DescriptionOptically pure (R)-enantiomer of 6-hydroxybuspirone (Axon 1996), a major active metabolite of Buspirone (Axon 1995); 5-HT1A partial agonist. (R)-Enantiomer showed higher affinity and selectivity for the 5HT1A receptor compared to the (S)-enantiomer; while (S)-Enantiomer has advantage of being cleared more slowly from blood compared to the (R)-enantiomer
5-HT1A partial agonist
Chemical name(R)-6-hydroxy-8-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)-8-azaspiro[4.5]decane-7,9-dione hydrochloride Parent CAS No.[477930-30-6] |
| 產(chǎn)品資料 |
