| 產(chǎn)品名稱 | ML 154 - NCGC 00185684 | NCGC 84 |
| 產(chǎn)品貨號 | Axon 2321 CAS [1345964-89-7] MF C29H26N2PS.BrMW 545.47 Purity: 99% Soluble in DMSO Description Competitive, selective, and brain penetrant NPS receptor antagonist that preferentially blocks NPS-induced ERK phosphorylation over intracellular Ca2+ or cAMP responses (IC50 values 22.1 nM, 36.5 nM, and 5.0 nM, in Ca2+, cAMP, and binding assays, respectively).?NCGC84 decreases alcohol self-administration in vivo, and does not inhibit the vasopressin V1b or the endogenous purinergic receptor at concentrations up to 10 μM. References Certificates Categories Extra info A. Thorsell et al. A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant.... J Neurosci. 2013 Jun 12;33(24):10132-42. doi: 10.1523/JNEUROSCI.4742-12.2013. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology CNS A6 NPSR Competitive, selective, and brain penetrant NPS receptor antagonist Chemical name 1-cinnamyl-3-(diphenylphosphorothioyl)-2-methyl-1H-imidazo[1,2-a]pyridin-4-ium bromide Parent CAS No. [1346105-73-4] Order Size Unit Price Stock 5 mg €120.00 In Stock |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
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| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
ML 154 - NCGC 00185684 | NCGC 84Axon 2321 CAS [1345964-89-7] MF C29H26N2PS.Br
DescriptionCompetitive, selective, and brain penetrant NPS receptor antagonist that preferentially blocks NPS-induced ERK phosphorylation over intracellular Ca2+ or cAMP responses (IC50 values 22.1 nM, 36.5 nM, and 5.0 nM, in Ca2+, cAMP, and binding assays, respectively).?NCGC84 decreases alcohol self-administration in vivo, and does not inhibit the vasopressin V1b or the endogenous purinergic receptor at concentrations up to 10 μM.
Competitive, selective, and brain penetrant NPS receptor antagonist
Chemical name1-cinnamyl-3-(diphenylphosphorothioyl)-2-methyl-1H-imidazo[1,2-a]pyridin-4-ium bromide Parent CAS No.[1346105-73-4] |
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