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產(chǎn)品名稱

BT-11

產(chǎn)品貨號

Axon 2749 CAS [1912399-75-7] MF C30H24N8O2MW 528.56 Purity: 99% Soluble in DMSO Description BT-11 is a first-in-class, orally active lanthionine synthetase C-like 2 (LANCL2) binding compound (Kd value of 7.7 μM) for treating inflammatory bowel disease (IBD). Moreover, BT-11 downregulates expression of pro-inflammatory cytokines (e.g., TNF-α or interferon-γ, which are hallmarks of IBD), and promotes IL-10-mediated anti-inflammatory responses in the GI tract. KEYWORDS: BT-11 | supplier | LANCL2 modulator | BT11 | BT 11 | CAS [1912399-75-7] | Abscisic acid | LANCL | Modulator | Receptors | IBD

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

BT-11

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 2749

CAS [1912399-75-7]

MF C30H24N8O2
MW 528.56

Purity: 99%
Soluble in DMSO

BT-11

Description

BT-11 is a first-in-class, orally active lanthionine synthetase C-like 2 (LANCL2) binding compound (Kd value of 7.7 μM) for treating inflammatory bowel disease (IBD). Moreover, BT-11 downregulates expression of pro-inflammatory cytokines (e.g., TNF-α or interferon-γ, which are hallmarks of IBD), and promotes IL-10-mediated anti-inflammatory responses in the GI tract.

A Carbo et al. An N,N-Bis(benzimidazolylpicolinoyl)piperazine (BT-11): A Novel Lanthionine Synthetase C-Like 2-Based Therapeutic for Inflammatory Bowel Disease. J Med Chem. 2016 Nov 23;59(22):10113-10126.

Certificate of Analysis
Material Safety Data Sheet

Diabetes & Metabolism Immunology Pain & Inflammation PI3K-Akt-mTOR Unclassified LANCL

First-in-class, orally active LANCL2 binding compound

Chemical name

Piperazine-1,4-diylbis((6-(1H-benzo[d]imidazol-2-yl)pyridin-2-yl)methanone)

Parent CAS No.

[1912399-75-7]

產(chǎn)品資料

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