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Axon 2496 CAS [457639-26-8] MF C18H16F3N3O2SMW 395.40 Purity: 100% Soluble in DMSO Description Celecoxib analog that lacks COX-2 inhibitory activity but exhibits anti-tumor properties; DMC reduced growth and initiated apoptotic cell death in several MM cell lines. Mechanistically, DMC down-regulates critical components of the cell-cycle machinery (cyclins A and B); blocks the activity of important mitogenic and survival pathways (MEK, NF-κB, STAT3, survivin); and leads to increased caspase activity. Moreover, DMC quite potently mimics the ability of celecoxib to stimulate the endoplasmic reticulum stress response (ESR) and subsequent cell death . References Certificates Categories Extra info A. Kardosh et al. Multitarget inhibition of drug-resistant multiple myeloma cell lines by dimethyl-celecoxib (DMC), a non-COX-2 inhibitory analog of celecoxib. Blood. 2005 Dec 15;106(13):4330-8. ? A. Kardosh et al. Dimethyl-celecoxib (DMC), a derivative of celecoxib that lacks cyclooxygenase-2-inhibitory function, potently mimics the anti-tumor effects of celecoxib on Burkitt's lymphoma in vitro and in vivo. Cancer Biol Ther. 2005 May;4(5):571-82. ? P. Pyrko et al. Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib. Mol Cancer Ther. 2007 Apr;6(4):1262-75. Certificate of Analysis Material Safety Data Sheet Angiogenesis Cardiovascular Cell Cycle Regulation Cell Signaling & Oncology NF-κB MAPK JAK-STAT Unclassified Celecoxib analog with anti-tumor properties, lacking COX-2 inhibitory activity Chemical name 4-(5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide Parent CAS No. [457639-26-8] Order Size Unit Price Stock 10 mg €75.00 In Stock

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現貨詢價，電話：010-67529703

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產品品牌

axonmedchem

產品概述

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Dimethylcelecoxib, 2,5- - DMC

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2496

CAS [457639-26-8]

MF C18H16F3N3O2S
MW 395.40

Purity: 100%
Soluble in DMSO

Dimethylcelecoxib, 2,5-

Description

Celecoxib analog that lacks COX-2 inhibitory activity but exhibits anti-tumor properties; DMC reduced growth and initiated apoptotic cell death in several MM cell lines. Mechanistically, DMC down-regulates critical components of the cell-cycle machinery (cyclins A and B); blocks the activity of important mitogenic and survival pathways (MEK, NF-κB, STAT3, survivin); and leads to increased caspase activity. Moreover, DMC quite potently mimics the ability of celecoxib to stimulate the endoplasmic reticulum stress response (ESR) and subsequent cell death .

A. Kardosh et al. Multitarget inhibition of drug-resistant multiple myeloma cell lines by dimethyl-celecoxib (DMC), a non-COX-2 inhibitory analog of celecoxib. Blood. 2005 Dec 15;106(13):4330-8.

A. Kardosh et al. Dimethyl-celecoxib (DMC), a derivative of celecoxib that lacks cyclooxygenase-2-inhibitory function, potently mimics the anti-tumor effects of celecoxib on Burkitt's lymphoma in vitro and in vivo. Cancer Biol Ther. 2005 May;4(5):571-82.

P. Pyrko et al. Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib. Mol Cancer Ther. 2007 Apr;6(4):1262-75.

Certificate of Analysis
Material Safety Data Sheet

Angiogenesis Cardiovascular Cell Cycle Regulation Cell Signaling & Oncology NF-κB MAPK JAK-STAT Unclassified

Celecoxib analog with anti-tumor properties, lacking COX-2 inhibitory activity

Chemical name

4-(5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide

Parent CAS No.

[457639-26-8]

產品資料

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