This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines.Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes.Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases.Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses.Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I).

Target	HEXA
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Tested Applications	ELISA, WB, FCM
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Purified recombinant fragment of human HEXA expressed in E. coli.
Purification	Purified antibody
Isotype	IgG2b
Conjugation	Unconjugated
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Molecular Weight	60.7 kDa
GeneID	3073 15211 300757
Concentration	1.0 mg/ml
Buffer	PBS with 0.05% sodium azide and 0.5% protein stabilizer.
UNSPSC Code	12352203
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.