Monocyte chemoattractant protein-1 (CCL2) is a member of the chemokine beta family of cytokines. The protein is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. It may play a inprotant role in the initiation and/or progression of pulmonary hypertension (PH). Blockade of a systemic CCL2 signal pathway in vivo may prevent PH.

Target	CCL2
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Tested Applications	ELISA, WB
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Purified recombinant fragment of human MCP-1 expressed in E. Coli.
Purification	Purified antibody
Isotype	IgG1.kappa
Conjugation	Unconjugated
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Molecular Weight	13 kDa
Swiss Prot	P13500
GeneID	6347
Gene Symbol	CCL2
OMIM	158105
HGNC	10618
Ensembl	ENSG00000108691
Concentration	1.0 mg/ml
Buffer	PBS containing 0.03% sodium azide.
UNSPSC Code	12352203
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.