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This antibody recognizes CD62L, known as L-selectin, a 76 kDa molecule which is a member of the selectin family of adhesion receptors. These function in leucocyte binding to activated endothelium and in lymphocyte homing to high endothelial venules. The antigen is expressed on neutrophils, monocytes, T and B lymphocyte subsets and NK cells. CD62L on neutrophils, but not on lymphocytes, carries the carbohydrate structure sialyl-Lewis X. This carbohydrate is ligand for the selectins P-selectin (CD62P) and E-selectin (CD62E) which can be expressed on endothelial cells, and the interaction of CD62L with these selectins has been argued to play a role in the initial adhesion of neutrophils to endothelium.

Target	CD62L
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Tested Applications	FCM
Recommended dilutions	FCM: 20 μl/1 million cells. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Tissue / cell preparation: Peripheral blood leukocytes.
Purification	Affinity Chromatography
Form	Liquid
Isotype	IgG2a
Conjugation	CF-Blue
Specificity	This antibody recognizes CD62L, known as L-selectin, a 76 kDa molecule which is a member of the selectin family of adhesion receptors. These function in leucocyte binding to activated endothelium and in lymphocyte homing to high endothelial venules. The antigen is expressed on neutrophils, monocytes, T and B lymphocyte subsets and NK cells. CD62L on neutrophils, but not on lymphocytes, carries the carbohydrate structure sialyl-Lewis X. This carbohydrate is ligand for the selectins P-selectin (CD62P) and E-selectin (CD62E) which can be expressed on endothelial cells, and the interaction of CD62L with these selectins has been argued to play a role in the initial adhesion of neutrophils to endothelium.
Storage	Aliquot and store in the dark at 2°C to 8°C. Avoid exposure to light.
Molecular Weight	76 kDa
Swiss Prot	P14151
GeneID	6402
Buffer	The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium Azide
UNSPSC Code	12352203
Availability	Shipped within 2-3 weeks.
Note	This product is for research use only.