| 產(chǎn)品名稱 | Anti-KLRB1C Mouse Monoclonal Antibody [clone: PK136] |
| 產(chǎn)品貨號(hào) | 70-5941-U100 |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | vwr |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
The PK136 antibody is specific for mouse NK1.1, a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. NK1.1 is prominently expressed on natural killer (NK) cells, and is correlated with NK cytotoxic effects toward virus-infected cells and tumor cells. NK1.1 is expressed on subsets of NKT cells in certain mouse strains (C57BL/6, FVB/N, and NZB), yet absent from others (AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129). Putative subsets of NK cells and their expression of NK1.1 antigen are of continuing interest, including NK1.1+/CD117+ (c-Kit) cells reported to be immunosuppressive for CD8+ T cells in a mechanism involving PD-1 and PD-L1 (Ehlers et al. 2012. Endocrinology. 10: 1247).
The PK136 antibody may be used for detection of NK1.1 expression on mouse strains including CE, B6, NZB, C58, Ma/My, ST, SJL, and FVB. The antibody is reported to react with an epitope common to NKR-P1B and NKR-P1C alloantigenic forms of NK1.1 (Carlyle et al. 2006. J. Immunol. 176: 7511-7524).
Type: Primary
Antigen: KLRB1C Clonality: Monoclonal Clone: PK136 Conjugation: Unconjugated Epitope: Host: Mouse Isotype: IgG2a Reactivity: Mouse |
| 產(chǎn)品資料 |
![Anti-KLRB1C Mouse Monoclonal Antibody [clone: PK136]](https://us.vwr.com/stibo/bigweb/std.lang.all/48/75/13484875.jpg "Anti-KLRB1C Mouse Monoclonal Antibody [clone: PK136]")