| 產(chǎn)品名稱(chēng) | Anti-CD8A Mouse Monoclonal Antibody (PE (Phycoerythrin)-Cy7?) [clone: OKT8] |
| 產(chǎn)品貨號(hào) | 60-0086-T100 |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢(xún)價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | vwr |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
The OKT8 antibody is specific for the 32-34 kDa alpha chain of human CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor for antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.
The OKT8 antibody is widely used as a phenotypic marker for CD8 on cytotoxic T cells, thymocytes, as well as on certain cell types that do not also express the TCR, including some NK cells and lymphoid dendritic cells. If used together with alternative antibodies Anti-Human CD8a clone RPA-T8 or Anti-Human CD8a clone Hit8a, the OKT8 antibody will not block binding of RPA-T8 or Hit8a.
Type: Primary
Antigen: CD8A Clonality: Monoclonal Clone: OKT8 Conjugation: PE (Phycoerythrin)-Cy7? Epitope: Host: Mouse Isotype: IgG2a Reactivity: |
| 產(chǎn)品資料 |
