| 產(chǎn)品名稱 | Anti-TNFRSF18 Rat Monoclonal Antibody (PE (Phycoerythrin)) [clone: DTA-1] |
| 產(chǎn)品貨號 | 50-5874-U100 |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | vwr |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
The DTA-1 antibody reacts with mouse CD357, also known as GITR or AITR (in humans), a 66-70 kDa member of the Tumor Necrosis Factor superfamily (TNFRSF18). GITR is primarily found on T cells, and its function may vary depending on the T cell type where it is expressed. GITR is upregulated on activated T cells where it provides co-stimulation, yet GITR may promote the inhibition of CD4+ CD25+ Treg cells, where it is expressed at high levels. GITR ligand (GITRL) is found on B cells, macrophages, dendritic and endothelial cells, and is implicated in regulating both innate and adaptive immune responses.
The DTA-1 antibody may be used for analysis of GITR expression on T cells, and is also commonly used in vitro as an agonistic antibody to induce GITR signaling in various assays.
Type: Primary
Antigen: TNFRSF18 Clonality: Monoclonal Clone: DTA-1 Conjugation: PE (Phycoerythrin) Epitope: Host: Rat Isotype: IgG2b Reactivity: Mouse |
| 產(chǎn)品資料 |
