| 產(chǎn)品名稱 | Anti-LRRC32 Mouse Monoclonal Antibody (FITC (Fluorescein Isothiocyanate)) [clone: GARP5] |
| 產(chǎn)品貨號 | 35-9882-T100 |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | vwr |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
The GARP5 antibody reacts with human GARP, also known as LRRC32 or Garpin, an 80 kDa transmembrane protein which acts as a receptor for the latent form of TGF-beta 1 (pro-TGF-beta), preventing its secretion. Specifically, GARP is reported to associate with the pro-domain of TGF-beta 1, known as latency-associated peptide (LAP), which must be cleaved to release the biologically active cytokine. The putative role of GARP in sequestering the TGF-beta is important for regulating its activity, as TGF-beta signaling is involved in development and function of Th17, Treg and many other immune cell types. GARP expression has been shown on platelets and at high levels on Foxp3+ Treg cells, where it is proposed to be a phenotypic identifier for activated human Treg cells.
The GARP5 antibody may be used for analysis of human GARP by flow cytometry, immunoprecipitation and Western blotting. Please choose the appropriate format for each application.
Type: Primary
Antigen: LRRC32 Clonality: Monoclonal Clone: GARP5 Conjugation: FITC (Fluorescein Isothiocyanate) Epitope: Host: Mouse Isotype: IgG1 Reactivity: Human |
| 產(chǎn)品資料 |
