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產(chǎn)品名稱

Recombinant Human OX40L (carrier-free) from BIOLEGEND

產(chǎn)品貨號(hào)

555704

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

25 μg

產(chǎn)品品牌

BIOLEGEND

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	Recombinant Human OX40L (carrier-free)
Description	OX40L is a member of the TNF superfamily of structurally related proteins that exists primarily as a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells (APCs), such as dendritic cells and activated B cells. It is also expressed on vascular endothelial cells, mast cells, and natural killer cells. OX40L signals specifically through the OX40 receptor (CD134), which is expressed predominantly on CD4+ T cells, as well as on certain activated CD8+ T cells. OX40-OX40L interaction function as a costimulatory signal that is required for a conducive interaction between antigen presenting cells and their target T cells. OX40L enhances cellular proliferation and survival of memory and effector cells, and increases expression of RANTES, IL-2, IL-3, and IFN-γ. This interaction also induces immunoglobulin secretion by activated B cells. Besides playing a role in asthma, it has been shown that plasmacytoid dendritic cells (DCs) infiltrating a melanoma microenvironment are able to promote proinflammatory Th2 and regulatory immune profiles through OX40L and ICOSL expression. This suggests that this molecule could potentially be a therapeutic target for cancer treatment.
Size	25 μg
Concentration	n/a
Applications	BA
Other Names	TNFSF4, CD252, GP34, CD134L, TXGP1
Gene, Accession, CAS #	Gene ID: 7292
Catalog #	555704
Price
Order / More Info	Recombinant Human OX40L (carrier-free) from BIOLEGEND
Product Specific References	n/a
產(chǎn)品資料

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