| 產品詳情 |
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| Product Name | TEPP-46 |
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| Description | TEPP-46 (ML-265) is a potent and selective PKM2 activator. TEPP-46 activates tumor-specific PKM2 (EC50 = 92 nM) by binding to the dimer-dimer interface between two subunits of PKM2 and inducing tetramerization, which is the most active form of the enzyme. In mice with A549 xenograft tumors, ML-265 displays good oral bioavailability with relatively low clearance, long half-life. MW: 372.5. Purity ≥98% by HPLC |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6-[(3-aminophenyl)methyl]-4,6-dihydro-4-methyl-2-(methylsulfinyl)-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one; CID-44246499,NCGC00186528, ML-265 |
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| Gene, Accession, CAS # | CAS: 1221186-53-3 |
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| Catalog # | B2164-5 |
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| Price | |
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| Order / More Info | TEPP-46 from BIOVISION, INC. |
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| Product Specific References | n/a |
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